Use of a sputum gene expression signature of 6 biomarkers can predict future exacerbation phenotypes in patients with moderate to severe asthma.
Inflammatory markers associated with COPD were linked to increased symptom burden, a greater number of exacerbations, and decreased 6-minute walk distance in smokers with preserved spirometry.
Improvements in pancreatic function biomarkers, including increases in fecal elastase-1 and decreases in serum immunoreactive trypsinogen, were seen in patients treated with lumacaftor and ivacaftor.
Wixela Inhub has been made available by Mylan for the treatment of asthma and COPD.
Researchers have found 12 variables that may be predictive of corticosteroid response in patients with severe asthma.
COPD is prone to false positive diagnoses.
Inhaled liposomal ciprofloxacin is associated with a longer median time to first pulmonary exacerbation vs placebo in patients with non-cystic fibrosis bronchiectasis and chronic P aeruginosa lung infection requiring antibiotic therapy.
School-based, self-managed asthma interventions appear to reduce hospital admissions, the number of days children experience asthma symptoms, and emergency department visits.
Tregony Simoneau, MD, a pediatric pulmonologist, shares her experiences with nonadherence in treating asthma.
A comprehensive research bronchoscopy procedure, including oral sampling, bronchoalveolar lavage, endobronchial biopsy, and brushing can be safely performed in COPD.
Neutrophilic inflammation in bronchoalveolar lavage from children with protracted bacterial bronchitis is associated with bacterial biomass but unrelated to alpha diversity.
Compared with dual therapy, triple therapy was associated with reduced risk for severe exacerbation of COPD and better FEV1.
A significant association was found between emergency department management failure in asthma and rs295137 in the Spermatogenesis Associated Serine Rich 2 Like gene.
Overweight/obese teenagers and young adults who took omega-3 fatty acid supplements did not have improved asthma control.
Mylan plans to make Wixela Inhub available in 3 strengths: 100mcg/50mcg, 250mcg/50mcg, and 500mcg/50mcg.
Nearly 6% of older adults account for more than 20% of emergency department visits.
In patients with moderate to severe COPD, indacaterol/glycopyrronium treatment is associated with improvements in regional ventilation and pulmonary microvascular blood flow.
Asthma in childhood is associated with a future risk for certain types of central nervous system defects in offspring.
Due to brain excitability and hypoxia from coughing, patients with cystic fibrosis have a propensity for cortical spreading depression and hemiplegic migraine.
Offspring of mothers with asthma had a reduced odds of having asthma themselves when the mothers were treated with a strategy guided by fraction of exhaled nitric oxide.