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Sputum 6 Gene Signature Predicts Future Asthma Exacerbation Frequency

Sputum 6 Gene Signature Predicts Future Asthma Exacerbation Frequency

Use of a sputum gene expression signature of 6 biomarkers can predict future exacerbation phenotypes in patients with moderate to severe asthma.

Inflammatory Markers in COPD Linked to Increased Symptom Burden in Smokers

Inflammatory Markers in COPD Linked to Increased Symptom Burden in Smokers

Inflammatory markers associated with COPD were linked to increased symptom burden, a greater number of exacerbations, and decreased 6-minute walk distance in smokers with preserved spirometry.

Biomarkers of Pancreatic Function in CF Improved With Lumacaftor/Ivacaftor

Biomarkers of Pancreatic Function in CF Improved With Lumacaftor/Ivacaftor

Improvements in pancreatic function biomarkers, including increases in fecal elastase-1 and decreases in serum immunoreactive trypsinogen, were seen in patients treated with lumacaftor and ivacaftor.

Advair Diskus Generic Now Available for COPD and Asthma

Advair Diskus Generic Now Available for COPD and Asthma

Wixela Inhub has been made available by Mylan for the treatment of asthma and COPD.

Machine Learning Helps Identify Variables of Corticosteroid Response in Asthma

Machine Learning Helps Identify Variables of Corticosteroid Response in Asthma

Researchers have found 12 variables that may be predictive of corticosteroid response in patients with severe asthma.

Buying Time to First Exacerbation in Non-Cystic Fibrosis Bronchiectasis

Buying Time to First Exacerbation in Non-Cystic Fibrosis Bronchiectasis

Inhaled liposomal ciprofloxacin is associated with a longer median time to first pulmonary exacerbation vs placebo in patients with non-cystic fibrosis bronchiectasis and chronic P aeruginosa lung infection requiring antibiotic therapy.

School-Based, Self-Managed Asthma Interventions May Reduce Hospitalizations

School-Based, Self-Managed Asthma Interventions May Reduce Hospitalizations

School-based, self-managed asthma interventions appear to reduce hospital admissions, the number of days children experience asthma symptoms, and emergency department visits.

Why Does Asthma Prevail? A Clinician's Opinion on Nonadherence

Why Does Asthma Prevail? A Clinician's Opinion on Nonadherence

Tregony Simoneau, MD, a pediatric pulmonologist, shares her experiences with nonadherence in treating asthma.

Comprehensive Research Bronchoscopy Procedure Safe, Tolerable in COPD

Comprehensive Research Bronchoscopy Procedure Safe, Tolerable in COPD

A comprehensive research bronchoscopy procedure, including oral sampling, bronchoalveolar lavage, endobronchial biopsy, and brushing can be safely performed in COPD.

Neutrophilic Inflammation in Bronchitis Associated With Multiple BAL Microbiota

Neutrophilic Inflammation in Bronchitis Associated With Multiple BAL Microbiota

Neutrophilic inflammation in bronchoalveolar lavage from children with protracted bacterial bronchitis is associated with bacterial biomass but unrelated to alpha diversity.

Triple Therapy Reduces COPD Exacerbation Risk Compared With Dual Therapy

Triple Therapy Reduces COPD Exacerbation Risk Compared With Dual Therapy

Compared with dual therapy, triple therapy was associated with reduced risk for severe exacerbation of COPD and better FEV1.

Asthma Management Failure in Emergency Department Linked to Genetic Factors

Asthma Management Failure in Emergency Department Linked to Genetic Factors

A significant association was found between emergency department management failure in asthma and rs295137 in the Spermatogenesis Associated Serine Rich 2 Like gene.

Omega-3 Supplements Do Not Improve Asthma Control in Overweight Patients

Omega-3 Supplements Do Not Improve Asthma Control in Overweight Patients

Overweight/obese teenagers and young adults who took omega-3 fatty acid supplements did not have improved asthma control.

First Generic Version of Advair Diskus Gets FDA Approval

First Generic Version of Advair Diskus Gets FDA Approval

Mylan plans to make Wixela Inhub available in 3 strengths: 100mcg/50mcg, 250mcg/50mcg, and 500mcg/50mcg.

COPD Common Condition in Frequent Users of Emergency Department

COPD Common Condition in Frequent Users of Emergency Department

Nearly 6% of older adults account for more than 20% of emergency department visits.

Indacaterol/Glycopyrronium Improves Regional Ventilation in COPD

Indacaterol/Glycopyrronium Improves Regional Ventilation in COPD

In patients with moderate to severe COPD, indacaterol/glycopyrronium treatment is associated with improvements in regional ventilation and pulmonary microvascular blood flow.

Does Prepregnancy Asthma Increase Central Nervous System Defect Risk in Offspring?

Does Prepregnancy Asthma Increase Central Nervous System Defect Risk in Offspring?

Asthma in childhood is associated with a future risk for certain types of central nervous system defects in offspring.

Cystic Fibrosis May Be a Risk Factor for Hemiplegic Migraine and Stroke

Cystic Fibrosis May Be a Risk Factor for Hemiplegic Migraine and Stroke

Due to brain excitability and hypoxia from coughing, patients with cystic fibrosis have a propensity for cortical spreading depression and hemiplegic migraine.

FENO Intervention Reduces Asthma in Offspring of Mothers With Asthma

FENO Intervention Reduces Asthma in Offspring of Mothers With Asthma

Offspring of mothers with asthma had a reduced odds of having asthma themselves when the mothers were treated with a strategy guided by fraction of exhaled nitric oxide.

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