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Optimizing Epilepsy Therapy: Case Study Involving a 19-Year-Old Male Who Is Nonadherent to His Current Regimen and Experiencing Breakthrough Seizures

Optimizing Epilepsy Therapy: Case Study Involving a 19-Year-Old Male Who Is Nonadherent to His Current Regimen and Experiencing Breakthrough Seizures


Expert Perspective

Time to Complete

45 minutes


February 22, 2017


February 22, 2018
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Maximum Credits

0.75 / AMA PRA Category 1 CreditTM

Accredited Provider

Provided by Haymarket Medical Education

Commercial Supporter

Supported by an educational grant from Sun Pharmaceutical Industries Ltd.

Program Description

Managing patients with epilepsy is a challenge and requires thorough knowledge of the various antiepileptic drugs (AEDs) available as well as the pharmacologic technologies associated with these treatments. Lack of treatment adherence may result in breakthrough seizures, which poses many risks for the patient. Clinicians managing epilepsy in clinical practice therefore need ongoing education to better treat their patients, including tools that will allow clinicians to better educate their patients on various strategies to improve adherence. This clinical consult between a primary care physician and a neurologist highlights some of the challenges that clinicians face when patients experience breakthrough seizures.

Intended Audience

Neurologists and primary care clinicians (internists, family physicians, general practitioners, nurse practitioners, physician assistants) engaged in the management of epilepsy

Educational Objectives

At the conclusion of this activity, participants should be better able to:

  • Identify patients diagnosed with partial-onset seizures who may be suboptimally treated or experiencing drug-resistant/refractory epilepsy
  • Differentiate the safety, efficacy, mechanisms of action (MOAs), and drug technologies among newer antiepileptic drugs (AEDs)
  • Formulate care plans with a patient‐centric approach and more effective patient/caregiver communication in regard to treatment options, pill burden, adherence, improving outcomes, and quality of life (QoL)

Conflict Of Interest Disclosure Policy

In accordance with the ACCME Standards for Commercial Support, HME requires that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any commercial interest. HME resolves all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all its educational activities.


Joseph I. Sirven, MD
Professor of Neurology
Chairman, Department of Neurology
Mayo Clinic
Scottsdale, AZ

Dr. Sirven has received consulting fees from Acorda Therapeutics, Inc.; NeuroPace, Inc.; UCB, Inc.; and Upsher-Smith Laboratories, Inc.

Sheryl Haut, MD
Director, Adult Epilepsy Program
Montefiore Medical Center
Albert Einstein College of Medicine
Bronx, NY

Dr. Haut has received consulting fees from Acorda Therapeutics, Inc., and Siga Technologies, Inc., and research grants from GW Pharmaceuticals.

Faculty Reviewer
Marcello Morgan, MD, MPH, CHCP

Associate Medical Director
Haymarket Medical Education
Paramus, NJ

Dr. Morgan has nothing to disclose with regard to commercial support.

Accredited Provider Disclosure

Haymarket Medical Education staff involved in the planning and content review of this activity have no relevant financial relationships to disclose.




AMA PRA Category 1 Credit(s)TM

Accreditation Statement

Haymarket Medical Education is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Designation Statement

Haymarket Medical Education designates this enduring material for a maximum of 0.75 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Disclosure of Unlabeled Use

This CME activity may or may not discuss investigational, unapproved, or off-label use of drugs. Participants are advised to consult prescribing information for any products discussed. The information provided in this CME activity is for continuing medical education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options for a specific patient’s medical condition.


The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of Haymarket Medical Education and Sun Pharmaceutical Industries Ltd. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

If you have any questions relating to the accreditation of this activity, please contact


To obtain credit, a score of 70% or better on the post-test is required. This activity is offered at no cost to participants. Please proceed with the activity until you have successfully completed this program, answered all test questions, completed the post-test and evaluation, and have received a digital copy of your credit certificate. Your online certificate will be saved on myCME within your Profile/CME History, which you can access at any time.

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