Pneumonia

Absence of Alveolar Neutrophilia Predictive of Negative Bacterial Pneumonia

Absence of Alveolar Neutrophilia Predictive of Negative Bacterial Pneumonia

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Patients undergoing evaluation for ventilator-associated pneumonia who had an alveolar neutrophil percentage 90% for bacterial pneumonia.

Culture Negative Pneumonia Rates Linked to Higher PM<sub>2.5</sub> Concentrations

Culture Negative Pneumonia Rates Linked to Higher PM2.5 Concentrations

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Increases in the relative rates of culture negative pneumonia that required hospitalization or emergency department visits were significantly associated with increased concentrations of fine particulate air pollution.

Combining Corticosteroids and Antibiotics May Be Cost-Effective in CAP

Combining Corticosteroids and Antibiotics May Be Cost-Effective in CAP

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Treating severe community-acquired pneumonia with a combination of corticosteroids and antibiotics may be a cost-effective strategy.

Invasive Pneumococcal Disease Risk Higher in Premature Infants

Invasive Pneumococcal Disease Risk Higher in Premature Infants

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Invasive pneumococcal disease was significantly higher in premature infants than in infants born at term.

PCV13 Vaccine Protects Against Serotype 3 Invasive Pneumococcal Disease in Children

PCV13 Vaccine Protects Against Serotype 3 Invasive Pneumococcal Disease in Children

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A meta-analysis of case-control studies supports the use of the 13-valent pneumococcal conjugate vaccine in children as it protects against serotype 3.

Hypersensitivity Pneumonitis Prognosis by Phenotype

Hypersensitivity Pneumonitis Prognosis by Phenotype

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Compared with idiopathic pulmonary fibrosis, nonhoneycomb hypersensitivity pneumonitis phenotypes are associated with greater improvements in percent-predicted forced vital capacity.

Bacterial Pneumonia Associated With Increased Risk for Future MACE

Bacterial Pneumonia Associated With Increased Risk for Future MACE

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Patients with bacterial pneumonia are at higher risk for major adverse cardiovascular events within 90 days compared with patients with viral pneumonia.

Hands Are Vehicles for Transmission of <i>Streptococcus pneumoniae</i>

Hands Are Vehicles for Transmission of Streptococcus pneumoniae

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Hands can be vehicles for transmission of pneumococcus and lead to acquisition of nasopharyngeal colonization.

Healthcare-Associated Infections on Decline

Healthcare-Associated Infections on Decline

The risk of having a healthcare-associated infection was 16% lower in 2015 than in 2011.

New CHEST Guideline for Acute Cough Due to Suspected Pneumonia or Influenza

New CHEST Guideline for Acute Cough Due to Suspected Pneumonia or Influenza

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The CHEST Expert Cough Panel agreed on cough, dyspnea, pleural pain, sweating, shivers, aches, temperature of ≥38°C, tachypnea, and new and localizing chest examination signs as clinical symptoms as criteria suggestive of pneumonia in outpatient adults.

Pneumococcal Vaccine Recs Cause Confusion Among Healthcare Providers

Pneumococcal Vaccine Recs Cause Confusion Among Healthcare Providers

Survey finds variance in provider knowledge of adult pneumococcal vaccine recommendations.

Poor Lung Function in Infants From Maternal Exposure to Household Air Pollution

Poor Lung Function in Infants From Maternal Exposure to Household Air Pollution

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Significant associations were seen between increased average prenatal carbon monoxide and reduced time to peak tidal expiratory flow to expiratory time, increased respiratory rate, and increased minute ventilation.

Antipseudomonal Monotherapy Efficacious in Pneumonia

Antipseudomonal Monotherapy Efficacious in Pneumonia

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Antipseudomonal combination therapy has shown poorer efficacy than antipseudomonal monotherapy in individuals with suspected pseudomonal pneumonia.

Pneumococcal <i>H Influenzae</i> Protein D Conjugate Vaccine Effective in Children

Pneumococcal H Influenzae Protein D Conjugate Vaccine Effective in Children

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The burden of childhood and infant pneumonia can be effectively reduced through the use of the pneumococcal Haemophilus influenzae protein D conjugate vaccine.

PCV13 in Young Adults With Diabetes Could Avert Pneumonia Hospitalizations

PCV13 in Young Adults With Diabetes Could Avert Pneumonia Hospitalizations

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PCV13 in adults age <65 years with diabetes could reduce a substantial number of pneumonia hospitalizations.

Antibiotic Stewardship May Aid Stepdown Therapies for Community-Acquired Pneumonia

Antibiotic Stewardship May Aid Stepdown Therapies for Community-Acquired Pneumonia

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The use of fluoroquinolones in stable patients with community-acquired pneumonia can be reduced with stewardship programs that share antibiotic use data and provide guidance for step-down therapy.

Omadacycline Approved for Community-Acquired Bacterial Pneumonia

Omadacycline Approved for Community-Acquired Bacterial Pneumonia

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The FDA has approved Nuzyra for the treatment of adult patients with CABP and acute bacterial skin and skin structure infections.

Fluoroquinolones May Aid in Reducing Mortality in Community-Acquired Pneumonia

Fluoroquinolones May Aid in Reducing Mortality in Community-Acquired Pneumonia

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For patients with CAP, antibiotic regimens including a fluoroquinolone may reduce mortality risk by 1-2% compared to beta-lactams and cephalosporins alone.

Risk Factors for Multidrug-Resistant Pathogens in Pneumonia

Risk Factors for Multidrug-Resistant Pathogens in Pneumonia

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Previous antibiotic use and mechanical invasive ventilation were risk factors for multidrug-resistant pathogens in hospital-associated or ventilator-associated pneumonia.

Corticosteroids May Prevent Myocardial Infarction in Community-Acquired Pneumonia

Corticosteroids May Prevent Myocardial Infarction in Community-Acquired Pneumonia

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Patients with community-acquired pneumonia who received corticosteroids had a lower incidence of myocardial infarction compared with those who did not.

Multivalent Pneumococcal Conjugate Vaccine Gets Breakthrough Tx Designation

Multivalent Pneumococcal Conjugate Vaccine Gets Breakthrough Tx Designation

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The Breakthrough designation follows an FDA examination of results from a Phase 2 randomized, double-blind trial which evaluated the safety and immunogenicity of the treatment in adults aged 60 to 64 years.

Positive Results for Zerbaxa in Phase 3 Study of Ventilated HABP, VABP Patients

Positive Results for Zerbaxa in Phase 3 Study of Ventilated HABP, VABP Patients

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The full findings from the study will be presented at a future scientific conference; Merck plans to include the data in a supplemental New Drug Application for Zerbaxa which will be submitted to the Food and Drug Administration.

Coadjuvant Corticosteroids in Influenza Pneumonia Increases ICU Mortality

Coadjuvant Corticosteroids in Influenza Pneumonia Increases ICU Mortality

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Corticosteroids should not be used concomitantly with antiviral therapy in patients with influenza pneumonia.

Influenza an Independent Risk Factor for Invasive Pulmonary Aspergillosis

Influenza an Independent Risk Factor for Invasive Pulmonary Aspergillosis

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Influenza proved to be an independent risk factor for invasive pulmonary aspergillosis.

CURB-65 Tool in Community-Acquired Pneumonia Useful But Has Limitations

CURB-65 Tool in Community-Acquired Pneumonia Useful But Has Limitations

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The clinical prediction tool that uses confusion, uremia, elevated respiratory rate, and hypotension in community-acquired pneumonia demonstrated an association with ICU admittance.

Therapeutic Algorithm May Guide Empiric Therapy in Pneumonia

Therapeutic Algorithm May Guide Empiric Therapy in Pneumonia

An algorithm based on risk factors for resistant pathogens and illness severity can simplify pneumonia treatment, improve the accuracy of empiric therapy, reduce mortality, and help avoid overusing broad spectrum therapy in some patients.

Long-Term PPI Use Linked to Pneumonia Risk in Older Adults

Long-Term PPI Use Linked to Pneumonia Risk in Older Adults

Rate of incident pneumonia increased in second year after initiating treatment with proton pump inhibitors.

Coal Workers' Pneumoconiosis Deaths on the Decline

Coal Workers' Pneumoconiosis Deaths on the Decline

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Coal workers' pneumoconiosis deaths significantly decreased from 1999 to 2016 for residents ≥25 years.

Genome Sequencing Traces <i>K pneumoniae</i> Outbreak to Outpatient Clinic

Genome Sequencing Traces K pneumoniae Outbreak to Outpatient Clinic

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An investigation into an outbreak of NDM-producing Klebsiella pneumoniae across 2 Belgian hospitals identified an outpatient clinic as the likely common site of transfer and highlights the importance of infection control measures in outpatient settings.

Omadacycline Gets FDA Committee Nod for Skin Infections, Pneumonia

Omadacycline Gets FDA Committee Nod for Skin Infections, Pneumonia

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The Committee's recommendation was based on data from the omadacycline global development program that included nearly 2000 adults in three Phase 3 studies.

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