The Committee's recommendation was based on data from the omadacycline global development program that included nearly 2000 adults in three Phase 3 studies.
Inappropriate antibiotic prescriptions were highest among urgent care facilities (45.7%), with emergency departments (24.6%), medical offices (17.0%), and retail clinics (14.4%) following.
Most children who died of pneumococcus and Haemophilus influenzae type b presented with pneumonia.
Advanced diagnostic platforms to identify viruses can help patients with severe lower respiratory tract infections avoid unnecessary diagnostic testing, reduce antibiotic use, and initiate antiviral therapy.
To investigate what impact antibiotic treatment duration has on CAP outcomes, researchers from the Warren Alpert Medical School of Brown University conducted a search of various databases for studies comparing the safety and efficacy of treatment regimens lasting ≤6 days (short) and ≥7 days (long).
Investigators examined the incidence and outcomes of pneumonia in patients with acute ischemic stroke and type 2 diabetes.
Most deaths related to community-acquired pneumonia that occurred at tertiary-case hospitals were not preventable.
The real-world effectiveness of PCV13 vaccine in preventing hospitalization for vaccine-type community-acquired pneumonia was assessed.
Although clinical presentation was similar in both community-acquired pneumonia and non-pneumonia exacerbations, CRP, glucose, and leukocytes were higher in the former vs the latter.
Early clinical response rates were similar across PORT risk class subgroups in patients with community-acquired bacterial pneumonia when treated with omadacycline or moxifloxacin.
PCV13, marketed as Prevnar 13, was evaluated in a test-negative case-control study in real-world conditions where patients were administered pneumococcal vaccination as advised by their healthcare providers.
In the LEAP 2 study (N=738), patients with moderate CABP received either oral lefamulin 600mg every 12 hours for 5 days or oral moxifloxacin 400mg once daily for 7 days.
Clinicians should consider these findings when using atypical antipsychotics in patients at risk for pneumonia.
Researchers have developed a novel algorithm to identify hypersensitivity pneumonitis.
Lung ultrasound was more effective in diagnosing pediatric community-acquired pneumonia than chest radiography.
Clinical presentation and outcomes in HIV-infected patients with Legionella pneumonia did not differ from patients without HIV infection.
Low-dose computed tomography may assist clinicians in modifying diagnosis of elderly patients who are admitted with suspected pneumonia.
A higher proportion of patients with COPD and a blood eosinophil count of ≥0.34×109/L had elevated markers of low-grade systemic inflammation regardless of forced expiratory volume in 1 second.
The risk for death in patients with community-acquired pneumonia who were given mechanical ventilation does not seem to be affected by the presence of acute respiratory distress syndrome.
Researchers found increased myocardial infarction rates during the week after Streptococcus pneumoniae and influenza infections.
Differences in serum inflammatory markers may exist between patients with community-acquired pneumonia who present within the first 48 hours of symptom onset vs those who present later.
Use of prophylactic antimicrobial therapy was not associated with a reduction in mortality or transfer to critical care compared with patients managed with supportive care only.
Adults with community-acquired pneumonia that is visualized on CT scan but not on concurrent chest radiograph have similar pathogens, disease severity, and outcomes as patients who had pneumonia confirmed via chest radiograph.
Interventional reduction of the angiopoietin-1/angiopoietin-2 ratio may provide therapeutic perspective for prevention of acute lung injury in pneumonia.
Children with asthma who experience chronic oral glucocorticoid exposure may have significant morbidities, including adrenal suppression, recurrent pneumonia, and behavioral problems.
Researchers retrospectively analyzed data from patients hospitalized with pneumococcal community-acquired pneumonia to determine risk factors for pneumococcal bacteremia.
As a result of activating the inflammatory-immune system, pneumonia may trigger cardiovascular complications.
Researchers found the strongest link between prescription opioid use and the risk for invasive pneumococcal disease was present in individuals using long-acting, high-dose, or highly potent formulations.
Long-acting, high-potency, and high-dose opioids were associated with an increased risk for invasive pneumococcal disease.
Invasive mechanical ventilation in patients with severe community-acquired pneumonia appeared to increase their mortality risk.