Pneumonia

Omadacycline Noninferior to Moxifloxacin in Community-Acquired Pneumonia

Omadacycline Noninferior to Moxifloxacin in Community-Acquired Pneumonia

The second study showed that omadacycline was noninferior to linezolid in acute bacterial skin and skin-structure infections.

Omadacyline Now Available in IV, Oral Forms for CABP, ABSSSI

Omadacyline Now Available in IV, Oral Forms for CABP, ABSSSI

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Nuzyra, an aminomethylcycline (related to tetracycline antibiotics), is designed to overcome tetracycline resistance and has broad-spectrum activity against Gram-positive, Gram-negative and atypical bacteria, and other drug-resistant strains.

FDA Grants Breakthrough Therapy to 15-Valent Pneumococcal Conjugate Vaccine

FDA Grants Breakthrough Therapy to 15-Valent Pneumococcal Conjugate Vaccine

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Phase 3 studies investigating safety, tolerability, and immunogenicity in both adults and children are currently underway.

Benzodiazepine Use May Increase Risk for Pneumonia

Benzodiazepine Use May Increase Risk for Pneumonia

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Patients who either are currently or have recently taken benzodiazepines may have an increased risk for pneumonia.

Resist the Script: Antibiotic Overuse in Pneumonia — An Expert Roundtable

Resist the Script: Antibiotic Overuse in Pneumonia — An Expert Roundtable

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A shift toward personalized medicine in pneumonia management would involve refining the diagnostic categories to include viral pneumonia, bacterial pneumonia, and noninfectious respiratory disease.

Worse Outcomes in Community-Acquired Pneumonia Linked to Higher FGF21 Levels

Worse Outcomes in Community-Acquired Pneumonia Linked to Higher FGF21 Levels

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Patients diagnosed with community-acquired pneumonia with higher levels of fibroblast growth factor-21 may have higher mortality rates and longer hospitalizations.

Bacterial Pneumonia-Complicating Influenza: Risks, Morbidity, and Mortality

Bacterial Pneumonia-Complicating Influenza: Risks, Morbidity, and Mortality

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Diagnosing coinfection in pneumonia can be challenging because of timing of the sample collection and false-negative results when the viruses replicate in the lower respiratory tract.

Does CAP Antibiotic Prescribing Differ in Children's vs Non-Children's Hospitals?

Does CAP Antibiotic Prescribing Differ in Children's vs Non-Children's Hospitals?

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Guideline-concordant prescribing trends in pediatric community-acquired pneumonia appear to be lagging behind in non-children's hospitals compared with children's hospitals.

Child Pneumonia Rate Dropped Globally From 2000 to 2015

Child Pneumonia Rate Dropped Globally From 2000 to 2015

The number of clinical pneumonia episodes in children younger than 5 years of age was reduced by 22% in developing countries.

Influenza Seroconversion Risk Factors in Adults Hospitalized for Pneumonia

Influenza Seroconversion Risk Factors in Adults Hospitalized for Pneumonia

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Adults hospitalized for pneumonia who received an influenza vaccination during their stay were less likely to seroconvert if they had diabetes, bacterial detection, baseline seropositive titers for influenza B, or influenza vaccination in the previous season.

NDAs Submitted for Oral, IV Formulations of Lefamulin for CABP

NDAs Submitted for Oral, IV Formulations of Lefamulin for CABP

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Nabriva Therapeutics announced the submission of 2 NDAs to the FDA for the oral and IV formulations of lefamulin for the treatment of community-acquired bacterial pneumonia.

Pneumococcal Vaccine May Reduce Resistant <i>Streptococcus Pneumoniae</i> Carriage

Pneumococcal Vaccine May Reduce Resistant Streptococcus Pneumoniae Carriage

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A marked and rapid reduction in PCV13 serotype, the most common antibiotic-nonsusceptible S pneumoniae, carriage was observed in both ethnic populations included in this study.

Worse Outcomes From <i>Legionella</i> Pneumonia in Individuals With Advanced HIV

Worse Outcomes From Legionella Pneumonia in Individuals With Advanced HIV

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Previous results stated that Legionella pneumonia characteristics may not differ between individuals with HIV and individuals who do not have HIV.

Absence of Alveolar Neutrophilia Predictive of Negative Bacterial Pneumonia

Absence of Alveolar Neutrophilia Predictive of Negative Bacterial Pneumonia

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Patients undergoing evaluation for ventilator-associated pneumonia who had an alveolar neutrophil percentage 90% for bacterial pneumonia.

Culture Negative Pneumonia Rates Linked to Higher PM<sub>2.5</sub> Concentrations

Culture Negative Pneumonia Rates Linked to Higher PM2.5 Concentrations

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Increases in the relative rates of culture negative pneumonia that required hospitalization or emergency department visits were significantly associated with increased concentrations of fine particulate air pollution.

Combining Corticosteroids and Antibiotics May Be Cost-Effective in CAP

Combining Corticosteroids and Antibiotics May Be Cost-Effective in CAP

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Treating severe community-acquired pneumonia with a combination of corticosteroids and antibiotics may be a cost-effective strategy.

Invasive Pneumococcal Disease Risk Higher in Premature Infants

Invasive Pneumococcal Disease Risk Higher in Premature Infants

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Invasive pneumococcal disease was significantly higher in premature infants than in infants born at term.

PCV13 Vaccine Protects Against Serotype 3 Invasive Pneumococcal Disease in Children

PCV13 Vaccine Protects Against Serotype 3 Invasive Pneumococcal Disease in Children

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A meta-analysis of case-control studies supports the use of the 13-valent pneumococcal conjugate vaccine in children as it protects against serotype 3.

Hypersensitivity Pneumonitis Prognosis by Phenotype

Hypersensitivity Pneumonitis Prognosis by Phenotype

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Compared with idiopathic pulmonary fibrosis, nonhoneycomb hypersensitivity pneumonitis phenotypes are associated with greater improvements in percent-predicted forced vital capacity.

Bacterial Pneumonia Associated With Increased Risk for Future MACE

Bacterial Pneumonia Associated With Increased Risk for Future MACE

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Patients with bacterial pneumonia are at higher risk for major adverse cardiovascular events within 90 days compared with patients with viral pneumonia.

Hands Are Vehicles for Transmission of <i>Streptococcus pneumoniae</i>

Hands Are Vehicles for Transmission of Streptococcus pneumoniae

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Hands can be vehicles for transmission of pneumococcus and lead to acquisition of nasopharyngeal colonization.

Healthcare-Associated Infections on Decline

Healthcare-Associated Infections on Decline

The risk of having a healthcare-associated infection was 16% lower in 2015 than in 2011.

New CHEST Guideline for Acute Cough Due to Suspected Pneumonia or Influenza

New CHEST Guideline for Acute Cough Due to Suspected Pneumonia or Influenza

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The CHEST Expert Cough Panel agreed on cough, dyspnea, pleural pain, sweating, shivers, aches, temperature of ≥38°C, tachypnea, and new and localizing chest examination signs as clinical symptoms as criteria suggestive of pneumonia in outpatient adults.

Pneumococcal Vaccine Recs Cause Confusion Among Healthcare Providers

Pneumococcal Vaccine Recs Cause Confusion Among Healthcare Providers

Survey finds variance in provider knowledge of adult pneumococcal vaccine recommendations.

Poor Lung Function in Infants From Maternal Exposure to Household Air Pollution

Poor Lung Function in Infants From Maternal Exposure to Household Air Pollution

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Significant associations were seen between increased average prenatal carbon monoxide and reduced time to peak tidal expiratory flow to expiratory time, increased respiratory rate, and increased minute ventilation.

Antipseudomonal Monotherapy Efficacious in Pneumonia

Antipseudomonal Monotherapy Efficacious in Pneumonia

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Antipseudomonal combination therapy has shown poorer efficacy than antipseudomonal monotherapy in individuals with suspected pseudomonal pneumonia.

Pneumococcal <i>H Influenzae</i> Protein D Conjugate Vaccine Effective in Children

Pneumococcal H Influenzae Protein D Conjugate Vaccine Effective in Children

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The burden of childhood and infant pneumonia can be effectively reduced through the use of the pneumococcal Haemophilus influenzae protein D conjugate vaccine.

PCV13 in Young Adults With Diabetes Could Avert Pneumonia Hospitalizations

PCV13 in Young Adults With Diabetes Could Avert Pneumonia Hospitalizations

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PCV13 in adults age <65 years with diabetes could reduce a substantial number of pneumonia hospitalizations.

Antibiotic Stewardship May Aid Stepdown Therapies for Community-Acquired Pneumonia

Antibiotic Stewardship May Aid Stepdown Therapies for Community-Acquired Pneumonia

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The use of fluoroquinolones in stable patients with community-acquired pneumonia can be reduced with stewardship programs that share antibiotic use data and provide guidance for step-down therapy.

Omadacycline Approved for Community-Acquired Bacterial Pneumonia

Omadacycline Approved for Community-Acquired Bacterial Pneumonia

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The FDA has approved Nuzyra for the treatment of adult patients with CABP and acute bacterial skin and skin structure infections.

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