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Promethazine DM
Cough and cold
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Drug Name:

Promethazine DM Rx

Generic Name and Formulations:
Promethazine HCl 6.25mg, dextromethorphan HBr 15mg; per 5mL; liq; contains alcohol 7%.

Various generic manufacturers

Therapeutic Use:

Indications for Promethazine DM:

Cough and upper respiratory symptoms associated with allergy and common cold.


5mL every 4–6hrs; max 30mL/24hrs.


<2yrs: not recommended. 2–6yrs: 1.25–2.5mL every 4–6hrs; max 10mL/24hrs. 6–12yrs: 2.5–5mL every 4–6hrs; max 20mL/24hrs.


Concomitant MAOIs. Comatose states. Lower respiratory tract symptoms. Asthma.


Children <2yrs: potential for fatal respiratory depression. Atopic children. Compromised respiratory function (eg, COPD, apnea), signs/symptoms of Reye's syndrome or hepatic disease in children: avoid. Seizure disorder. Bone-marrow depression. Narrow-angle glaucoma. GI or GU obstruction. Peptic ulcer. Cardiovascular disease. Hepatic impairment. Debilitated. Elderly. Sedated patients or those confined to supine position. Avoid prolonged sun exposure. Labor & delivery. Pregnancy (Cat.C). Nursing mothers.

Pharmacological Class:

Antihistamine + antitussive.


See Contraindications. Increased extrapyramidal effects with MAOIs. Concomitant epinephrine: not recommended. Increased CNS depression with concomitant CNS depressants (eg, alcohol, sedatives/hypnotics, narcotics, general anesthesia, tricyclics); may need to reduce dose. Caution with other anticholinergics. May get false pregnancy test results.

Adverse Reactions:

Drowsiness, dizziness, confusion, sedation, insomnia, convulsive seizures, hallucinations, hyperexcitability, GI upset, respiratory depression, cardiovascular effects; possible neuroleptic malignant syndrome, cholestatic jaundice, blood dyscrasias.

How Supplied:

Contact supplier.

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