Maintenance and Reliever Digital System vs Standard Care Improves Asthma Control

Digitally integrated inhalers allow patients and clinicians to track and review inhaler usage and inhalation quality, which may improve outcomes in patients with asthma.

A maintenance and reliever digital system (MRDS) shows greater odds of inducing meaningful clinical improvements in patients with asthma after 6 months vs standard of care (SoC) maintenance and reliever inhalers, according to study findings presented at the American College of Allergy, Asthma & Immunology (ACAAI) Annual Scientific Meeting, held from November 10 to 14, 2022, in Louisville, Kentucky.

Researchers conducted the randomized prospective CONNECT2 study (ClinicalTrials.gov Identifier: NCT04677959) that comprised 391 participants aged at least 13 years with suboptimal asthma control measured by the Asthma Control Test (ACT). Participants were randomly assigned to receive either MRDS (n=210) SoC (n=181). They used Bayesian statistical analysis to determine a posterior probability distribution for odds ratios with corresponding credible intervals (CrI).

The primary endpoint was the probability of greater odds of reaching significant improvement in asthma control at 6 months. Meaningful improvement was defined as an ACT score greater than or equal to 20 or an increase of at least 3 units at 6 months from the ACT baseline score.

After 6 months, participants using the MRDS had greater odds of clinically meaningful improvements in asthma control vs SoC.

The researchers found an 88.7% probability of greater odds of achieving improvements in asthma control for participants receiving MRDS vs those receiving SoC after 6 months (mean odds ratio [MRDS/SoC], 1.35, 95% CrI, 0.846-2.038). This ratio reflected an average of 35% higher odds of achieving meaningful asthma control improvement for participants in the MRDS group vs those in the SoC group.

The study authors conclude, “After 6 months, participants using the MRDS had greater odds of clinically meaningful improvements in asthma control vs SoC.

References:

Mosnaim G, Hoyte F, Safioti G, et al. Effectiveness of a maintenance and reliever digital system to improve asthma control. Ann Allergy Asthma Immunol. 2022;125(5):S40-S41. doi:10.1016/j.anai.2022.08.619