Bronchiolitis obliterans is the leading cause of morbidity and mortality in the pulmonary transplant population with ≥50% of patients who receive a lung transplant developing the condition within 5 years.
Targeting TGF-β signaling in a tissue-specific manner allows the drug to modulate the fibrotic cascade with maximum clinical effects while avoiding adverse events.
An expert panel developed suggestions for chronic cough management in interstitial lung disease, but more clinical trials are needed to establish recommendations.
Pfizer has terminated the ALLOZITHRO trial (N=480) due to this increased risk.
Many patients with idiopathic pulmonary fibrosis in an international phase 4 study tolerated combination therapy with pirfenidone and nintedanib.
Compared with individuals who had stable idiopathic pulmonary fibrosis, those with an acute exacerbation had a significantly shorter survival, especially at the 3 year follow-up.
Low nailfold capillary density is associated with impaired pulmonary function tests and more frequent high-resolution computed tomography abnormalities in patients with juvenile dermatomyositis.
In patients with end-stage interstitial lung disease, there was a higher rate of survival to transplantation with venoarterial extracorporeal membrane oxygenation.
Double lung transplantation appears to offer superior survival outcomes to single lung transplantation in patients with interstitial pulmonary fibrosis who are younger than 70 years.
Extracorporeal membrane oxygenation (ECMO) for severe acute respiratory distress syndrome did not show a 60-day mortality benefit compared with conventional ventilation and ECMO rescue therapy. More adverse events occurred in the ECMO group with respect to bleeding requiring transfusion and severe thrombocytopenia.
Recombinant human pentraxin 2 therapy resulted in a slower decline in lung function in patients with idiopathic pulmonary fibrosis.
The variables for the stepwise echocardiographic score included right ventricular systolic pressure, early pulmonary regurgitation gradient, right atrial area size, tricuspid regurgitation velocity, left ventricle eccentricity index, and right ventricle fractional area change.
In patients with very severe acute respiratory distress syndrome, 60-day mortality was not significantly lower with venovenous extracorporeal membrane oxygenation than with conventional treatment.
The initiative helped reduce the ordering of chest radiographs, respiratory viral testing, and bronchodilators.
The frequency of migraine and sarcoidosis comorbidity was examined in a cohort study.
Experts in interstitial lung disease identified 18 items of importance for diagnosing chronic hypersensitivity pneumonitis.
Treatment for gastroesophageal reflux significantly reduced mortality in idiopathic pulmonary fibrosis and improved transplant-free survival.
Researchers identified independent predictors of short-term dermatomyositis- or polymyositis-related interstitial lung disease mortality.
RP5063 is a new chemical entity with a novel mechanism of multimodal modulation of serotonin and dopamine signaling pathways.
The risk for death in patients with community-acquired pneumonia who were given mechanical ventilation does not seem to be affected by the presence of acute respiratory distress syndrome.