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Treatment for Bronchiolitis Obliterans Gains Orphan Drug Status

Treatment for Bronchiolitis Obliterans Gains Orphan Drug Status

Bronchiolitis obliterans is the leading cause of morbidity and mortality in the pulmonary transplant population with ≥50% of patients who receive a lung transplant developing the condition within 5 years.

Anti-Fibrotic Drug Gets Orphan Drug Status for Idiopathic Pulmonary Fibrosis

Anti-Fibrotic Drug Gets Orphan Drug Status for Idiopathic Pulmonary Fibrosis

Targeting TGF-β signaling in a tissue-specific manner allows the drug to modulate the fibrotic cascade with maximum clinical effects while avoiding adverse events.

Chronic Cough in Interstitial Lung Disease: More Clinical Trials Needed

Chronic Cough in Interstitial Lung Disease: More Clinical Trials Needed

An expert panel developed suggestions for chronic cough management in interstitial lung disease, but more clinical trials are needed to establish recommendations.

FDA: Cancer Relapse Linked to Azithromycin Use to Prevent Serious Lung Condition

FDA: Cancer Relapse Linked to Azithromycin Use to Prevent Serious Lung Condition

Pfizer has terminated the ALLOZITHRO trial (N=480) due to this increased risk.

Nintedanib and Pirfenidone Tolerated in Idiopathic Pulmonary Fibrosis

Nintedanib and Pirfenidone Tolerated in Idiopathic Pulmonary Fibrosis

Many patients with idiopathic pulmonary fibrosis in an international phase 4 study tolerated combination therapy with pirfenidone and nintedanib.

Lung Transplant Survival Lower During Acute Exacerbations of IPF

Lung Transplant Survival Lower During Acute Exacerbations of IPF

Compared with individuals who had stable idiopathic pulmonary fibrosis, those with an acute exacerbation had a significantly shorter survival, especially at the 3 year follow-up.

Low Nailfold Capillary Density Associated With Lung Involvement in Juvenile Dermatomyositis

Low Nailfold Capillary Density Associated With Lung Involvement in Juvenile Dermatomyositis

Low nailfold capillary density is associated with impaired pulmonary function tests and more frequent high-resolution computed tomography abnormalities in patients with juvenile dermatomyositis.

Venoarterial ECMO Improves Survival to Transplant in Interstitial Lung Disease

Venoarterial ECMO Improves Survival to Transplant in Interstitial Lung Disease

In patients with end-stage interstitial lung disease, there was a higher rate of survival to transplantation with venoarterial extracorporeal membrane oxygenation.

Double Lung Transplantation Improves Survival in Interstitial Pulmonary Fibrosis

Double Lung Transplantation Improves Survival in Interstitial Pulmonary Fibrosis

Double lung transplantation appears to offer superior survival outcomes to single lung transplantation in patients with interstitial pulmonary fibrosis who are younger than 70 years.

ECMO for severe ARDS does not improve mortality

Extracorporeal membrane oxygenation (ECMO) for severe acute respiratory distress syndrome did not show a 60-day mortality benefit compared with conventional ventilation and ECMO rescue therapy. More adverse events occurred in the ECMO group with respect to bleeding requiring transfusion and severe thrombocytopenia.

Recombinant Human Pentraxin 2 Slowed Lung Function Decline in IPF

Recombinant Human Pentraxin 2 Slowed Lung Function Decline in IPF

Recombinant human pentraxin 2 therapy resulted in a slower decline in lung function in patients with idiopathic pulmonary fibrosis.

Composite Echo Score Predicts PH in Interstitial Lung Disease

Composite Echo Score Predicts PH in Interstitial Lung Disease

The variables for the stepwise echocardiographic score included right ventricular systolic pressure, early pulmonary regurgitation gradient, right atrial area size, tricuspid regurgitation velocity, left ventricle eccentricity index, and right ventricle fractional area change.

60-Day Mortality Not Significantly Lower With ECMO in ARDS

60-Day Mortality Not Significantly Lower With ECMO in ARDS

In patients with very severe acute respiratory distress syndrome, 60-day mortality was not significantly lower with venovenous extracorporeal membrane oxygenation than with conventional treatment.

Initiative Cuts Overuse of Tests, Treatments for Bronchiolitis

Initiative Cuts Overuse of Tests, Treatments for Bronchiolitis

The initiative helped reduce the ordering of chest radiographs, respiratory viral testing, and bronchodilators.

Migraine a Common Comorbidity in Individuals With Sarcoidosis

Migraine a Common Comorbidity in Individuals With Sarcoidosis

The frequency of migraine and sarcoidosis comorbidity was examined in a cohort study.

Expert Consensus on Chronic Hypersensitivity Pneumonitis Diagnostic Criteria

Expert Consensus on Chronic Hypersensitivity Pneumonitis Diagnostic Criteria

Experts in interstitial lung disease identified 18 items of importance for diagnosing chronic hypersensitivity pneumonitis.

Idiopathic Pulmonary Fibrosis Outcomes Improved by Gastroesophageal Reflux Treatment

Idiopathic Pulmonary Fibrosis Outcomes Improved by Gastroesophageal Reflux Treatment

Treatment for gastroesophageal reflux significantly reduced mortality in idiopathic pulmonary fibrosis and improved transplant-free survival.

Predictors Identified for Myositis-Related Interstitial Lung Disease Mortality

Predictors Identified for Myositis-Related Interstitial Lung Disease Mortality

Researchers identified independent predictors of short-term dermatomyositis- or polymyositis-related interstitial lung disease mortality.

Treatment for Idiopathic Pulmonary Fibrosis Gets Orphan Drug Designation

Treatment for Idiopathic Pulmonary Fibrosis Gets Orphan Drug Designation

RP5063 is a new chemical entity with a novel mechanism of multimodal modulation of serotonin and dopamine signaling pathways.

Mortality in Mechanically Ventilated Community-Acquired Pneumonia With or Without ARDS

Mortality in Mechanically Ventilated Community-Acquired Pneumonia With or Without ARDS

The risk for death in patients with community-acquired pneumonia who were given mechanical ventilation does not seem to be affected by the presence of acute respiratory distress syndrome.

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