Restrictive Lung Disease
Patients with interstitial lung disease who had honeycombing on chest computed tomography had higher mortality rates than patients without honeycombing.
Fewer than 25% of patients with idiopathic pulmonary fibrosis who were treated with the antifibrotic drug pirfenidone showed signs of disease progression.
Lung‐epithelial‐derived surfactant protein has been identified as a biomarker of systemic sclerosis-interstitial lung disease.
A new clinical practice guidelines summary for clinicians regarding idiopathic pulmonary fibrosis has been released, which describes clinical manifestations and diagnostic interventions for the disease.
Oral PBI-4050 alone or in combination with nintedanib or pirfenidone was well tolerated and associated with no serious adverse events in patients with idiopathic pulmonary fibrosis.
Associations were seen for both Alzheimer's disease-related dementia and cerebrovascular etiologies.
Prophylactic azithromycin may reduce hospital stays and the need for rescue antibiotics in patients with idiopathic pulmonary fibrosis.
Compared with idiopathic pulmonary fibrosis, nonhoneycomb hypersensitivity pneumonitis phenotypes are associated with greater improvements in percent-predicted forced vital capacity.
Researchers investigated whether increased IL-18 levels were associated with interstitial lung disease in rheumatoid arthritis.
The International Physical Activity Questionnaire long form is considered valid and consistent for measuring levels of physical activity in patients with fibrotic interstitial lung disease.
Pirfenidone May Be Effective for Improving Exercise Capacity, Dyspnea in Idiopathic Pulmonary FibrosisOctober 10, 2018
When treated with pirfenidone, patients with idiopathic pulmonary fibrosis experienced significant improvements in 6-minute walking distance and University of California San Diego Shortness of Breath Questionnaire scores.
Blacks experience a significantly higher rate of sarcoidosis-associated hospitalizations compared with whites.
Health-related quality of life and isolated exertional hypoxia in patients with interstitial lung disease may be improved by the use of ambulatory oxygen.
The primary objective was to characterize the long-term safety and tolerability of Ofev in patients with IPF; efficacy endpoints included annual rate of decline in forced vital capacity (FVC) calculated over 192 weeks.
Nintedanib plus sildenafil did not improve St. George's Respiratory Questionnaire scores in patients with idiopathic pulmonary fibrosis.
Although gastroesophageal reflux disease and idiopathic pulmonary fibrosis may be related, the association between the 2 disorders is most likely confounded by smoking.
The FDA's designation was based on data from a Phase 2 placebo-controlled trial that demonstrated pamrevlumab could potentially address an unmet medical need for this condition.
Laparoscopic antireflux surgery was safe and well tolerated in patients with idiopathic pulmonary fibrosis and abnormal acid gastroesophageal reflux.
Adding routine rheumatologic assessments to interstitial lung disease diagnosis could reduce the need for invasive procedures and improve diagnostic accuracy.
Rituximab is a safe and effective alternative to cyclophosphamide in managing the progression of scleroderma and subsequent development of interstitial lung disease.
Targeting TGF-β signaling in a tissue-specific manner allows the drug to modulate the fibrotic cascade with maximum clinical effects while avoiding adverse events.
An expert panel developed suggestions for chronic cough management in interstitial lung disease, but more clinical trials are needed to establish recommendations.
Many patients with idiopathic pulmonary fibrosis in an international phase 4 study tolerated combination therapy with pirfenidone and nintedanib.
Compared with individuals who had stable idiopathic pulmonary fibrosis, those with an acute exacerbation had a significantly shorter survival, especially at the 3 year follow-up.
Low nailfold capillary density is associated with impaired pulmonary function tests and more frequent high-resolution computed tomography abnormalities in patients with juvenile dermatomyositis.
In patients with end-stage interstitial lung disease, there was a higher rate of survival to transplantation with venoarterial extracorporeal membrane oxygenation.
Double lung transplantation appears to offer superior survival outcomes to single lung transplantation in patients with interstitial pulmonary fibrosis who are younger than 70 years.
Recombinant human pentraxin 2 therapy resulted in a slower decline in lung function in patients with idiopathic pulmonary fibrosis.
A Sarcoidosis Diagnostic Score tool was developed by comparing data from individuals with biopsy-confirmed sarcoidosis with that of individuals who did not have sarcoidosis.
The frequency of migraine and sarcoidosis comorbidity was examined in a cohort study.