Restrictive Lung Disease

CT Honeycombing in Interstitial Lung Disease Linked to Higher Mortality Rates

CT Honeycombing in Interstitial Lung Disease Linked to Higher Mortality Rates

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Patients with interstitial lung disease who had honeycombing on chest computed tomography had higher mortality rates than patients without honeycombing.

Pirfenidone Slows Long-Term Progression of Idiopathic Pulmonary Fibrosis

Pirfenidone Slows Long-Term Progression of Idiopathic Pulmonary Fibrosis

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Fewer than 25% of patients with idiopathic pulmonary fibrosis who were treated with the antifibrotic drug pirfenidone showed signs of disease progression.

Biomarkers Predictive of Systemic Sclerosis-Interstitial Lung Disease Identified

Biomarkers Predictive of Systemic Sclerosis-Interstitial Lung Disease Identified

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Lung‐epithelial‐derived surfactant protein has been identified as a biomarker of systemic sclerosis-interstitial lung disease.

Summary of 2018 Idiopathic Pulmonary Fibrosis Diagnostic Guidelines

Summary of 2018 Idiopathic Pulmonary Fibrosis Diagnostic Guidelines

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A new clinical practice guidelines summary for clinicians regarding idiopathic pulmonary fibrosis has been released, which describes clinical manifestations and diagnostic interventions for the disease.

New Idiopathic Pulmonary Fibrosis Treatment Safe, Likely Effective

New Idiopathic Pulmonary Fibrosis Treatment Safe, Likely Effective

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Oral PBI-4050 alone or in combination with nintedanib or pirfenidone was well tolerated and associated with no serious adverse events in patients with idiopathic pulmonary fibrosis.

Restrictive, Obstructive Lung Disease Linked to Dementia Risk

Restrictive, Obstructive Lung Disease Linked to Dementia Risk

Associations were seen for both Alzheimer's disease-related dementia and cerebrovascular etiologies.

Prophylactic Azithromycin Beneficial in Idiopathic Pulmonary Fibrosis

Prophylactic Azithromycin Beneficial in Idiopathic Pulmonary Fibrosis

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Prophylactic azithromycin may reduce hospital stays and the need for rescue antibiotics in patients with idiopathic pulmonary fibrosis.

Hypersensitivity Pneumonitis Prognosis by Phenotype

Hypersensitivity Pneumonitis Prognosis by Phenotype

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Compared with idiopathic pulmonary fibrosis, nonhoneycomb hypersensitivity pneumonitis phenotypes are associated with greater improvements in percent-predicted forced vital capacity.

High IL-18 Levels Associated With Interstitial Lung Disease in RA

High IL-18 Levels Associated With Interstitial Lung Disease in RA

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Researchers investigated whether increased IL-18 levels were associated with interstitial lung disease in rheumatoid arthritis.

Measuring Physical Activity Levels in Fibrotic Interstitial Lung Disease

Measuring Physical Activity Levels in Fibrotic Interstitial Lung Disease

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The International Physical Activity Questionnaire long form is considered valid and consistent for measuring levels of physical activity in patients with fibrotic interstitial lung disease.

Pirfenidone May Be Effective for Improving Exercise Capacity, Dyspnea in Idiopathic Pulmonary Fibrosis

Pirfenidone May Be Effective for Improving Exercise Capacity, Dyspnea in Idiopathic Pulmonary Fibrosis

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When treated with pirfenidone, patients with idiopathic pulmonary fibrosis experienced significant improvements in 6-minute walking distance and University of California San Diego Shortness of Breath Questionnaire scores.

Trends in Sarcoidosis-Related Hospitalizations in the United States

Trends in Sarcoidosis-Related Hospitalizations in the United States

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Blacks experience a significantly higher rate of sarcoidosis-associated hospitalizations compared with whites.

Ambulatory Oxygen Improves Interstitial Lung Disease Quality of Life

Ambulatory Oxygen Improves Interstitial Lung Disease Quality of Life

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Health-related quality of life and isolated exertional hypoxia in patients with interstitial lung disease may be improved by the use of ambulatory oxygen.

Ofev Shown to Slow Idiopathic Pulmonary Fibrosis Progression Long-Term

Ofev Shown to Slow Idiopathic Pulmonary Fibrosis Progression Long-Term

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The primary objective was to characterize the long-term safety and tolerability of Ofev in patients with IPF; efficacy endpoints included annual rate of decline in forced vital capacity (FVC) calculated over 192 weeks.

No Benefit From Nintedanib Plus Sildenafil in Idiopathic Pulmonary Fibrosis

No Benefit From Nintedanib Plus Sildenafil in Idiopathic Pulmonary Fibrosis

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Nintedanib plus sildenafil did not improve St. George's Respiratory Questionnaire scores in patients with idiopathic pulmonary fibrosis.

Idiopathic Pulmonary Fibrosis and GERD: An Unclear Connection

Idiopathic Pulmonary Fibrosis and GERD: An Unclear Connection

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Although gastroesophageal reflux disease and idiopathic pulmonary fibrosis may be related, the association between the 2 disorders is most likely confounded by smoking.

FDA Fast-Tracks Pamrevlumab for Idiopathic Pulmonary Fibrosis

FDA Fast-Tracks Pamrevlumab for Idiopathic Pulmonary Fibrosis

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The FDA's designation was based on data from a Phase 2 placebo-controlled trial that demonstrated pamrevlumab could potentially address an unmet medical need for this condition.

Laparoscopic Antireflux Surgery for Treating Idiopathic Pulmonary Fibrosis

Laparoscopic Antireflux Surgery for Treating Idiopathic Pulmonary Fibrosis

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Laparoscopic antireflux surgery was safe and well tolerated in patients with idiopathic pulmonary fibrosis and abnormal acid gastroesophageal reflux.

Interstitial Lung Disease Diagnosis Improved Using Rheumatologic Assessment

Interstitial Lung Disease Diagnosis Improved Using Rheumatologic Assessment

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Adding routine rheumatologic assessments to interstitial lung disease diagnosis could reduce the need for invasive procedures and improve diagnostic accuracy.

Rituximab Safe and Efficacious Alternative Treatment for Scleroderma

Rituximab Safe and Efficacious Alternative Treatment for Scleroderma

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Rituximab is a safe and effective alternative to cyclophosphamide in managing the progression of scleroderma and subsequent development of interstitial lung disease.

Anti-Fibrotic Drug Gets Orphan Drug Status for Idiopathic Pulmonary Fibrosis

Anti-Fibrotic Drug Gets Orphan Drug Status for Idiopathic Pulmonary Fibrosis

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Targeting TGF-β signaling in a tissue-specific manner allows the drug to modulate the fibrotic cascade with maximum clinical effects while avoiding adverse events.

Chronic Cough in Interstitial Lung Disease: More Clinical Trials Needed

Chronic Cough in Interstitial Lung Disease: More Clinical Trials Needed

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An expert panel developed suggestions for chronic cough management in interstitial lung disease, but more clinical trials are needed to establish recommendations.

Nintedanib and Pirfenidone Tolerated in Idiopathic Pulmonary Fibrosis

Nintedanib and Pirfenidone Tolerated in Idiopathic Pulmonary Fibrosis

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Many patients with idiopathic pulmonary fibrosis in an international phase 4 study tolerated combination therapy with pirfenidone and nintedanib.

Lung Transplant Survival Lower During Acute Exacerbations of IPF

Lung Transplant Survival Lower During Acute Exacerbations of IPF

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Compared with individuals who had stable idiopathic pulmonary fibrosis, those with an acute exacerbation had a significantly shorter survival, especially at the 3 year follow-up.

Low Nailfold Capillary Density Associated With Lung Involvement in Juvenile Dermatomyositis

Low Nailfold Capillary Density Associated With Lung Involvement in Juvenile Dermatomyositis

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Low nailfold capillary density is associated with impaired pulmonary function tests and more frequent high-resolution computed tomography abnormalities in patients with juvenile dermatomyositis.

Venoarterial ECMO Improves Survival to Transplant in Interstitial Lung Disease

Venoarterial ECMO Improves Survival to Transplant in Interstitial Lung Disease

In patients with end-stage interstitial lung disease, there was a higher rate of survival to transplantation with venoarterial extracorporeal membrane oxygenation.

Double Lung Transplantation Improves Survival in Interstitial Pulmonary Fibrosis

Double Lung Transplantation Improves Survival in Interstitial Pulmonary Fibrosis

Double lung transplantation appears to offer superior survival outcomes to single lung transplantation in patients with interstitial pulmonary fibrosis who are younger than 70 years.

Recombinant Human Pentraxin 2 Slowed Lung Function Decline in IPF

Recombinant Human Pentraxin 2 Slowed Lung Function Decline in IPF

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Recombinant human pentraxin 2 therapy resulted in a slower decline in lung function in patients with idiopathic pulmonary fibrosis.

Sarcoidosis Diagnostic Score Enhances Disease Diagnosis

Sarcoidosis Diagnostic Score Enhances Disease Diagnosis

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A Sarcoidosis Diagnostic Score tool was developed by comparing data from individuals with biopsy-confirmed sarcoidosis with that of individuals who did not have sarcoidosis.

Migraine a Common Comorbidity in Individuals With Sarcoidosis

Migraine a Common Comorbidity in Individuals With Sarcoidosis

The frequency of migraine and sarcoidosis comorbidity was examined in a cohort study.

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