Restrictive Lung Disease
Targeting TGF-β signaling in a tissue-specific manner allows the drug to modulate the fibrotic cascade with maximum clinical effects while avoiding adverse events.
An expert panel developed suggestions for chronic cough management in interstitial lung disease, but more clinical trials are needed to establish recommendations.
Many patients with idiopathic pulmonary fibrosis in an international phase 4 study tolerated combination therapy with pirfenidone and nintedanib.
Compared with individuals who had stable idiopathic pulmonary fibrosis, those with an acute exacerbation had a significantly shorter survival, especially at the 3 year follow-up.
Low nailfold capillary density is associated with impaired pulmonary function tests and more frequent high-resolution computed tomography abnormalities in patients with juvenile dermatomyositis.
In patients with end-stage interstitial lung disease, there was a higher rate of survival to transplantation with venoarterial extracorporeal membrane oxygenation.
Double lung transplantation appears to offer superior survival outcomes to single lung transplantation in patients with interstitial pulmonary fibrosis who are younger than 70 years.
Recombinant human pentraxin 2 therapy resulted in a slower decline in lung function in patients with idiopathic pulmonary fibrosis.
A Sarcoidosis Diagnostic Score tool was developed by comparing data from individuals with biopsy-confirmed sarcoidosis with that of individuals who did not have sarcoidosis.
The frequency of migraine and sarcoidosis comorbidity was examined in a cohort study.
Experts in interstitial lung disease identified 18 items of importance for diagnosing chronic hypersensitivity pneumonitis.
Treatment for gastroesophageal reflux significantly reduced mortality in idiopathic pulmonary fibrosis and improved transplant-free survival.
Researchers identified independent predictors of short-term dermatomyositis- or polymyositis-related interstitial lung disease mortality.
RP5063 is a new chemical entity with a novel mechanism of multimodal modulation of serotonin and dopamine signaling pathways.
Several patients were treated for idiopathic pulmonary fibrosis were identified as dental personnel.
After being treated for pyelonephritis and discharged to a nursing facility, a 67-year-old woman presents to the emergency department with shortness of breath.
In patients with acute respiratory distress syndrome, cisatracurium does not improve mortality when compared with vecuronium, but is associated with improvements in other outcomes.
A significant enrichment of potential pathogens occurred in patients who smoked and who were admitted to the hospital for severe trauma.
Translational research has increased the understanding of the mechanisms of ventilator-induced lung injury.
Treatments for acute respiratory distress syndrome that have less evidence to support their use have been overused by clinicians.
Depression and anxiety may affect quality of life for patients with idiopathic pulmonary fibrosis.
A low tidal volume ventilation strategy in patients with acute respiratory distress syndrome demonstrated a trend toward improved mortality.
Researchers examined the efficacy of conservative vs liberal fluid management in ARDS on disease mortality.
Most patients with sarcoidosis have a good prognosis, but age, extensive fibrosis, and pulmonary hypertension are associated with an increase in mortality.
Azithromycin may be an effective treatment option for acute exacerbation of idiopathic pulmonary fibrosis.
Mechanical ventilation does not improve outcomes in IPF patients, lengthens hospital stays, and increases costs.
Fractional exhaled nitric oxide levels directly correlated to subclinical pulmonary disease activity in children with systemic lupus erythematosus.
One year after hospital discharge, high rates of acute respiratory distress survivors are jobless.
Abnormal chest radiographs were noted in patients with active uveitis of unknown origin.
The idiopathic pulmonary fibrosis algorithm has a sensitivity of 55.6% and positive predictive value of 42.2%.