Are High FeNO Levels Linked to Risk of Frequent Asthma Exacerbations?
How do FeNO levels in asthma affect disease burden, quality of life, and the need for OCS maintenance therapy?
Chronic Rhinosinusitis
FDA Needs More Data to Decide on Benralizumab for Nasal Polyposis
The sBLA includes data from the phase 3 OSTRO study, which showed that treatment with subcutaneously administered benralizumab led to statistically significant improvements.
Drug-Device Combo Looks Promising for Chronic Sinusitis
OPN-375 is currently marketed under the brand name Xhance for the treatment of nasal polyps in patients 18 years of age and older.
Dupilumab and Systemic Corticosteroid Use in Patients with CRSwNP and Asthma
Does dupilumab reduce the need for systemic corticosteroids in patients with chronic rhinosinusitis with nasal polyps and coexisting asthma?
Mepolizumab Improves Loss of Smell in Chronic Rhinosinusitis With Nasal Polyps
The phase 3 SYNAPSE clinical trial evaluated the efficacy of mepolizumab in improving sense of smell in patients with chronic rhinosinusitis with nasal polyps.
Chronic Rhinosinusitis With Nasal Polyps: Prevalence, Disease Burden Investigated
The authors utilized medical and pharmacy claims obtained from the Optum Clinformatics Data Mart Database.
Bronchiectasis in Patients With Overlapping Asthma and Chronic Rhinosinusitis
Investigators assessed the prevalence, inflammatory characteristics, and clinical implications of bronchiectasis in patients with overlapping asthma and chronic rhinosinusitis.
Nucala Approved for Chronic Rhinosinusitis With Nasal Polyps
The approval was based on data from the phase 3 SYNAPSE study that evaluated mepolizumab as an add-on maintenance treatment in over 400 adults with CRSwNP.
Benralizumab Looks Promising in Nasal Polyps Trial
The 56-week OSTRO trial evaluated the efficacy and safety of benralizumab, an interleukin-5 antagonist, in 413 adult patients with severe nasal polyposis.
FDA to Review Omalizumab for Chronic Rhinosinusitis With Nasal Polyps
The FDA has accepted for filing the sBLA for omalizumab for the treatment of adults with chronic rhinosinusitis with nasal polyps who have had an inadequate response to intranasal corticosteroids.
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