Omalizumab Inhibits Respiratory Reactions During Aspirin Desensitization
In patients with aspirin exacerbated respiratory disease, treatment with omalizumab resulted in “clinically silent” aspirin desensitization.
Treatments
Asthma Exacerbation Risk With As-Needed Budesonide-Formoterol vs Maintenance Budesonide
Budesonide-formoterol as needed was not inferior compared with budesonide maintenance therapy in terms of severe asthma exacerbation rates, but may be inferior for controlling symptoms.
Effectiveness of Budesonide-Formoterol vs Terbutaline in Asthma Symptom Control
There was a 60% lower rate of severe asthma exacerbations in individuals treated with budesonide-formoterol compared with individuals treated with terbutaline as needed.
Early Clinical Response With Omadacycline vs Moxifloxacin in CABP
Early clinical response rates were similar across PORT risk class subgroups in patients with community-acquired bacterial pneumonia when treated with omadacycline or moxifloxacin.
Prevnar 13 Linked to Reduced Risk of CAP Hospitalization in Older Patients
PCV13, marketed as Prevnar 13, was evaluated in a test-negative case-control study in real-world conditions where patients were administered pneumococcal vaccination as advised by their healthcare providers.
Mortality Increased With Liberal Oxygen Therapy in Acutely Ill Patients
Liberal supplemental oxygen therapy in acutely ill patients increased mortality during hospitalization, at 30 days, and at longest follow-up.
Positive Results Announced for Pleuromutilin Antibiotic in CABP
In the LEAP 2 study (N=738), patients with moderate CABP received either oral lefamulin 600mg every 12 hours for 5 days or oral moxifloxacin 400mg once daily for 7 days.
High-Flow Nasal Cannula vs Conventional Oxygen Therapy for Acute Respiratory Failure
In patients with acute respiratory failure, high-flow nasal cannula and conventional oxygen therapy provided similar benefits.
Tiotropium/Olodaterol Combination vs Tiotropium Alone for Severe COPD Exacerbations
Tiotropium may be more effective in reducing the rate of moderate and severe chronic obstructive pulmonary disorder exacerbations when used in combination with olodaterol vs tiotropium alone.
Budesonide Improved Epithelial Barrier Function in Asthma
Researchers evaluated barrier dysfunction by exposing viral models to budesonide, montelukast, formoterol, or a combination.
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