PPD Shortage Prompts CDC to Issue New Recommendations for TB Testing
The CDC announced an expected 3 to 10 month shortage of Aplisol used as an aid in the diagnosis of tuberculosis.
Tuberculosis
FDA Panel Votes on Treatment for Extensively Drug-Resistant, Multidrug-Resistant TB
The FDA’s Antimicrobial Drugs Advisory Committee voted in favor of pretomanid, as part of a combination regimen with bedaquiline and linezolid, for the treatment of pulmonary extensively drug resistant, treatment intolerant, or nonresponsive multidrug resistant tuberculosis.
TB Treatment Monitoring: Molecular Bacterial Load Assay vs Standard Testing
Compared with standard of care tests and most clinical signs, the molecular bacterial load assay demonstrated higher sensitivity and more rapid turnaround times for monitoring tuberculosis treatment.
Latent TB Detection: QuantiFERON-TB Gold Plus vs QuantiFERON-TB Gold In-Tube
Positive results with respect to the presence of latent tuberculosis infection in patients with renal failure were more consistent with the use of QuantiFERON-TB Gold Plus testing compared with the use of QuantiFERON-TB Gold In-Tube testing.
Mitigating Antibiotic Resistance in Respiratory Infections: An Expert Roundtable
Receiving appropriate antibiotic therapy in a timely manner is important, but clinicians must also consider potential antibiotic resistance in the hospital and surrounding community.
Low-Level Delamanid and Bedaquiline Resistance in Extremely Drug-Resistant TB
Researchers reported a case of drug resistance against 2 recently approved antitubercular medications: delamanid and bedaquiline.
Rifapentine Plus Isoniazid Noninferior to Isoniazid in HIV-Related TB
For prevention of TB in people with HIV, a single month regimen of rifapentine plus isoniazid was noninferior to 9 months of isoniazid alone.
CDC: Tuberculosis Incidence Declined in United States in 2017
Number of tuberculosis cases and incidence decreased globally, but more progress is needed to meet targets.
QuantiFERON-TB Gold-Plus Performance in Children With Confirmed Tuberculosis
The new interferon-gamma release assay QuantiFERON-TB Gold Plus had good sensitivity in children with pulmonary tuberculosis.
Building a Tuberculosis-Free World
The first-ever UN High-Level Meeting on tuberculosis, in September 2018, resolved that ending the disease is a global priority.
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