Effect of Combination vs Triple Therapy on COPD Exacerbations

Effect of Combination vs Triple Therapy on COPD Exacerbations

Combination therapy with LABA and LAMA yielded a lower annualized rate of COPD exacerbations compared with triple therapy.

Macrolides for Asthma Management: An Updated Review

Macrolides for Asthma Management: An Updated Review

While macrolides had no direct effect on lung function, their use significantly improved asthma control and quality of life in patients with asthma.

Fixed vs Auto-Adjusting CPAP for Prevention of eGFR Decline in OSA

Fixed vs Auto-Adjusting CPAP for Prevention of eGFR Decline in OSA

Fixed continuous positive airway pressure for the treatment of obstructive sleep apnea was associated with preventing a time-dependent decline in estimated glomerular filtration rate.

Beclomethasone Dipropionate vs Cetirizine in Children With Perennial Allergic Rhinitis

Beclomethasone Dipropionate vs Cetirizine in Children With Perennial Allergic Rhinitis

Nasal beclomethasone dipropionate was more effective in improving nasal patency and cytology as well as quality of life compared with cetirizine in children with perennial allergic rhinitis.

Initiative Cuts Overuse of Tests, Treatments for Bronchiolitis

Initiative Cuts Overuse of Tests, Treatments for Bronchiolitis

The initiative helped reduce the ordering of chest radiographs, respiratory viral testing, and bronchodilators.

Most Concerning Med Issues Explored Among Youth With Asthma

Most Concerning Med Issues Explored Among Youth With Asthma

The study authors reported, "The most commonly reported problems by youth were: (a) hard to remember when to take the asthma medication (54%) and (b) hard to use asthma medication at school (34%)."

Oral Anticoagulant Effective in Recurrent VTE Prevention in Cancer Patients

Oral Anticoagulant Effective in Recurrent VTE Prevention in Cancer Patients

At the end of 6 months, the rate of VTE recurrence was 4% among rivaroxaban patients vs 11% in the dalteparin arm (hazard ratio [HR] 0.43, 95% CI: 0.19 to 0.99).

Feasibility of At-Home Use Injectable Tx for Severe Asthma Assessed

Feasibility of At-Home Use Injectable Tx for Severe Asthma Assessed

Of the total 573 APFS dispensed, 1 malfunctioned and 1 was considered nonfunctional because it was not returned. The study authors also reported that patient-use error only led to 2 unsuccessful at-home administrations.

ICS Therapy May Not Be Enough for Asthma Patients With Elevated Eosinophils

ICS Therapy May Not Be Enough for Asthma Patients With Elevated Eosinophils

The study aimed to determine the association between ICS therapy adherence and the occurrence of asthma exacerbations in patients with high blood eosinophil levels.

Copeptin May Serve as Prognostic Biomarker for Pulmonary Embolism

Copeptin May Serve as Prognostic Biomarker for Pulmonary Embolism

Copeptin may be useful for identifying normotensive patients with pulmonary embolism who have a higher risk for an adverse outcome.

Assessing Depression Following Inpatient COPD Rehabilitation

Assessing Depression Following Inpatient COPD Rehabilitation

PHQ-9 and PHQ-2 show factorial validity, invariance, and reliability for measuring depression in patients with chronic obstructive pulmonary disease.

Survival Rates With Parenteral Prostanoids in Pulmonary Arterial Hypertension

Survival Rates With Parenteral Prostanoids in Pulmonary Arterial Hypertension

In patients with pulmonary arterial hypertension who were treated with a parenteral prostanoid, survival was linked with the number of guideline-recommended lower-risk and higher-risk criteria attained.

COPD, Asthma, or Asthma COPD Overlap Syndrome: Diagnostic Challenges

COPD, Asthma, or Asthma COPD Overlap Syndrome: Diagnostic Challenges

Emerging guidelines for diagnosing and treating asthma COPD overlap syndrome will help clinicians better manage patients and prevent serious adverse effects.

Opsumit sNDA Submitted for Chronic Thromboembolic Pulmonary Hypertension

Opsumit sNDA Submitted for Chronic Thromboembolic Pulmonary Hypertension

The sNDA is accompanied by results from the MERIT-1 trial, a Phase 2 randomized, placebo-controlled, double-blind study which assessed the efficacy, safety and tolerability of macitentan 10mg in 80 patients with inoperable CTEPH.

Children With Status Asthmaticus Do Not Benefit From Magnesium Sulfate

Children With Status Asthmaticus Do Not Benefit From Magnesium Sulfate

Children with status asthmaticus who received magnesium sulfate therapy were on continuous albuterol for a longer duration.

Stem Cell Therapy for RV Failure in PAH: Overview and Clinician Interview

Stem Cell Therapy for RV Failure in PAH: Overview and Clinician Interview

Stem cell therapy targeting right ventricular failure may help improve pulmonary circulation in pulmonary arterial hypertension.

Addition of Olodaterol to Tiotropium Does Not Significantly Reduce COPD Exacerbations

Addition of Olodaterol to Tiotropium Does Not Significantly Reduce COPD Exacerbations

Adding olodaterol to tiotropium did not significantly reduce exacerbations in patients with chronic obstructive pulmonary disease as much as researchers had anticipated.

Trelegy Ellipta Gains Expanded COPD Indication, Loses Boxed Warning

Trelegy Ellipta Gains Expanded COPD Indication, Loses Boxed Warning

The drug consists of fluticasone furoate, an inhaled corticosteroid (ICS), umeclidinium, a long-acting muscarinic antagonist, and vilanterol, a long-acting beta2-adrenergic agonist (LABA), delivered via an Ellipta dry powder inhaler.

ACOG: Updated Recommendations for Influenza Vaccination During Pregnancy

ACOG: Updated Recommendations for Influenza Vaccination During Pregnancy

This updated Committee Opinion includes more recent data on the safety and efficacy of influenza vaccination during pregnancy, as well as recommendations for treatment and postexposure chemoprophylaxis.

Transcatheter vs Surgical Aortic Valve Replacement in COPD

Transcatheter vs Surgical Aortic Valve Replacement in COPD

In patients with COPD, transcatheter aortic valve replacement was associated with fewer respiratory-related complications than surgical aortic valve replacement.

Breathing New Life Into COPD and Asthma Therapy With Statins

Breathing New Life Into COPD and Asthma Therapy With Statins

Statins have anti-inflammatory and anti-oxidative effects, which could reduce exacerbations of both asthma and chronic obstructive pulmonary disease.

Adult Caregivers Likely to Receive Influenza Vaccination From Pediatric Clinics

Adult Caregivers Likely to Receive Influenza Vaccination From Pediatric Clinics

Adult caretaker influenza vaccination cocooning programs can prove beneficial and financially successful in private practice models where external funding is limited or not available.

Triple Therapy Tied to Reduced Rate of COPD Exacerbations

Triple Therapy Tied to Reduced Rate of COPD Exacerbations

Triple therapy with fluticasone furoate, umeclidinium, and vilanterol was associated with a lower rate of exacerbations in chronic obstructive pulmonary disease.

Paracetamol Overuse During Cold and Flu Season

Paracetamol Overuse During Cold and Flu Season

During the cold and flu season, the use and over-dosing of paracetamol is common, and may partially be driven by higher use of over-the-counter combination medications for the treatment of upper respiratory cold/flu symptoms.

Chest Tube Placement vs Needle Aspiration for Spontaneous Pneumothorax

Chest Tube Placement vs Needle Aspiration for Spontaneous Pneumothorax

Both chest tube placement and needle aspiration were considered acceptable treatments for primary spontaneous pneumothorax.

Adjuvant Pembrolizumab Beneficial in Metastatic NSCLC

Adjuvant Pembrolizumab Beneficial in Metastatic NSCLC

Nivolumab plus ipilimumab linked to better survival in NSCLC with high tumor mutational burden.

No significant benefit of long-acting muscarinic antagonists over long-acting beta-agonists in reducing exacerbation risk in uncontrolled, persistent asthma

Adjunct long-acting muscarinic antagonist (LAMA) use with corticosteroids was associated with reduced exacerbation risk compared with placebo in patients with uncontrolled, persistent asthma. However, LAMA, long-acting beta-agonist (LABA), and inhaled corticosteroids (triple therapy) were not associated with lower risk for exacerbations compared with LABA and inhaled corticosteroids alone.

Balanced crystalloids decreases adverse kidney events compared to saline among critically ill patients: The SMART trial

Use of balanced crystalloids (lactated Ringers or Plasma-Lyte A) was associated with a significant reduction in acute kidney injury events compared with normal saline among intensive care unit (ICU) patients. Use of balanced crystalloids was also associated with lower though nonsignificant in-hospital mortality at 30-days after admission.

AASM: Medical Marijuana Should Not Be Used to Treat Sleep Apnea

AASM: Medical Marijuana Should Not Be Used to Treat Sleep Apnea

Continuous positive airway pressure (CPAP) remains the mainstay of medical treatment for OSA.

Fixed-Dosed Dual Bronchodilators for COPD: Overview and Clinician Interview

Fixed-Dosed Dual Bronchodilators for COPD: Overview and Clinician Interview

Treating chronic obstructive pulmonary disease remains challenging, particularly in terms of choosing the appropriate fixed-dose combination bronchodilator.

Bedaquiline and Delamanid Effective in Multidrug-Resistant Tuberculosis

Bedaquiline and Delamanid Effective in Multidrug-Resistant Tuberculosis

Bedaquiline and delamanid were effective and well tolerated in patients with multidrug-resistant tuberculosis.

Oral Treprostinil Dosing Characteristics in Pulmonary Arterial Hypertension

Oral Treprostinil Dosing Characteristics in Pulmonary Arterial Hypertension

Prescribers tend to favor a frequency of 3 times per day for oral treprostinil dosing in patients with pulmonary arterial hypertension.

Treatment for Idiopathic Pulmonary Fibrosis Gets Orphan Drug Designation

Treatment for Idiopathic Pulmonary Fibrosis Gets Orphan Drug Designation

RP5063 is a new chemical entity with a novel mechanism of multimodal modulation of serotonin and dopamine signaling pathways.

Respiratory Muscle Training in Multiple Sclerosis: Assessing the Evidence

Respiratory Muscle Training in Multiple Sclerosis: Assessing the Evidence

Early intervention in the case of respiratory compromise in patients with multiple sclerosis has the potential to prevent infection and maintain pulmonary function.

Asthma Exacerbation Risk Lower With SMART Therapy

Asthma Exacerbation Risk Lower With SMART Therapy

In patients with persistent asthma, single maintenance and reliever therapy was associated with a lower risk for exacerbations compared with inhaled corticosteroids as controller therapy and short-acting beta-agonists as relief therapy.

Mortality in Mechanically Ventilated Community-Acquired Pneumonia With or Without ARDS

Mortality in Mechanically Ventilated Community-Acquired Pneumonia With or Without ARDS

The risk for death in patients with community-acquired pneumonia who were given mechanical ventilation does not seem to be affected by the presence of acute respiratory distress syndrome.

Tai Chi Helps Improve Respiratory Function in COPD

Tai Chi Helps Improve Respiratory Function in COPD

Tai chi found to be as effective as pulmonary rehabilitation for patients with chronic obstructive pulmonary disease.

Polypharmacy Linked to Poorer Cognitive, Physical Capability

Polypharmacy Linked to Poorer Cognitive, Physical Capability

Researchers found stronger negative associations for participants with polypharmacy between the ages of 60 and 64 years and at 69 years.

Debating Noninvasive vs Invasive Ventilation in Acute Exacerbations of COPD

Debating Noninvasive vs Invasive Ventilation in Acute Exacerbations of COPD

It is still not known whether differences in mortality rates between patients who receive noninvasive vs invasive ventilation for acute exacerbations of COPD can be attributed to less severe disease or other factors.

Omalizumab Effective in Severe Allergic Asthma, Regardless of Eosinophil Level

Omalizumab Effective in Severe Allergic Asthma, Regardless of Eosinophil Level

Regardless of blood eosinophil count, omalizumab was an effective treatment in adult and pediatric patients with severe allergic asthma.

Dacomitinib Granted Priority Review for NSCLC With EGFR-Activating Mutations

Dacomitinib Granted Priority Review for NSCLC With EGFR-Activating Mutations

Dacomitinib is a pan-human epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor.

Novel Cystic Fibrosis Treatment Granted Fast Track Status

Novel Cystic Fibrosis Treatment Granted Fast Track Status

Proteostasis Therapeutics is developing the combination treatment which includes a novel transmembrane conductance regulator (CFTR) amplifier (PTI-428), a third generation corrector (PTI-801) and a potentiator (PTI-808).

Most Patients Select Suboptimal Medications for Allergic Rhinitis

Most Patients Select Suboptimal Medications for Allergic Rhinitis

Only 16.5% of pharmacy customers with hay fever select optimal medications.

Lonhala Magnair Now Available for Long-Term COPD Maintenance

Lonhala Magnair Now Available for Long-Term COPD Maintenance

Lonhala Magnair is available as a 25mcg strength inhalation solution per 1mL vial.

Sinuva Sinus Implant Launched to Treat Recurrent Nasal Polyps

Sinuva Sinus Implant Launched to Treat Recurrent Nasal Polyps

Sinuva can be implanted during a routine physician visit under local or topical anesthesia.

Duration of Antibiotics Often Exceeds Guidelines for Sinusitis

Duration of Antibiotics Often Exceeds Guidelines for Sinusitis

More than 90% of non-azithromycin antibiotic courses were 10 days or longer for acute sinusitis.

Two Inhalers Go Head-to-Head in COPD Exacerbation Study

Two Inhalers Go Head-to-Head in COPD Exacerbation Study

Study authors concluded, "Combining tiotropium and olodaterol did not reduce exacerbation rate as much as expected compared with tiotropium alone."

NDA for Novel Amikacin Inhalation Submitted for Rare Lung Infection

NDA for Novel Amikacin Inhalation Submitted for Rare Lung Infection

ALIS has previously been designated orphan drug status, breakthrough therapy status and a Qualified Infectious Disease Product.

COPD: Disease Management Care vs Recommended Care Alone

COPD: Disease Management Care vs Recommended Care Alone

Disease management added to recommended care in chronic obstructive pulmonary disease was not superior to recommended care alone.

Efficacy of Different Doses of Glycopyrronium Via a Metered Dose Inhaler in COPD

Efficacy of Different Doses of Glycopyrronium Via a Metered Dose Inhaler in COPD

Four different doses of glycopyrronium delivered via metered dose inhaler were compared for safety and efficacy in the treatment of chronic obstructive pulmonary disease.

Prevent Treatment Nonadherence in Asthma, COPD: Build Strong Patient Relationships

Prevent Treatment Nonadherence in Asthma, COPD: Build Strong Patient Relationships

Patients with asthma or chronic obstructive pulmonary disease have especially high rates of nonadherence, even in comparison with other chronic diseases.

Smartinhaler Sensor for Symbicort Will Be Available Over-the-Counter

Smartinhaler Sensor for Symbicort Will Be Available Over-the-Counter

The Smartinhaler sensor is a device installed onto a patient's inhaler to monitor and promote asthma and COPD medication adherence.

Delirium in ICU Prevented With Nocturnal Administration of Dexmedetomidine

Delirium in ICU Prevented With Nocturnal Administration of Dexmedetomidine

A higher percentage of critically ill patients in the intensive care unit who were given nocturnal dexmedetomidine remained delirium free compared with placebo.

No Benefit From Prophylactic Antimicrobials in Aspiration Pneumonitis

No Benefit From Prophylactic Antimicrobials in Aspiration Pneumonitis

Use of prophylactic antimicrobial therapy was not associated with a reduction in mortality or transfer to critical care compared with patients managed with supportive care only.

Effectiveness of Daily vs Thrice-Weekly Tuberculosis Regimens in HIV Patients

Effectiveness of Daily vs Thrice-Weekly Tuberculosis Regimens in HIV Patients

HIV-positive patients with pulmonary tuberculosis benefited from daily antituberculosis therapy in terms of effectiveness and rifampicin resistance.

Asthma Exacerbation Risk Reduced With Inhaled Corticosteroids Plus LABAs or LAMAs

Asthma Exacerbation Risk Reduced With Inhaled Corticosteroids Plus LABAs or LAMAs

Long-acting muscarinic antagonists or long-acting β-agonists plus inhaled corticosteroids lowered the risk for asthma exacerbations vs adjuvant placebo.

Shorter Tuberculosis Treatment Regimens Linked to Better Completion Rates

Shorter Tuberculosis Treatment Regimens Linked to Better Completion Rates

Shorter treatment regimens for tuberculosis were associated with increased completion rates and fewer adverse events compared with traditional regimens.

Suicide Risk Not Increased With Oseltamivir in Pediatric Patients

Suicide Risk Not Increased With Oseltamivir in Pediatric Patients

There was no significant correlation with suicide for oseltamavir exposure or for influenza diagnosis alone.

Prophylactic haloperidol not linked to improved survival in ICU patients: The REDUCE trial

Prophylactic haloperidol did not reduce delirium incidence, delirium-free days, duration of mechanical ventilation, or hospital length of stay in patients in the intensive care unit.

Adjunctive glucocorticoid therapy does not lower mortality in septic shock

Patients with septic shock in the intensive care unit undergoing mechanical ventilation and managed with adjunctive continuous hydrocortisone infusion did not have a lower 90-day mortality compared with placebo.

Increased inhaled glucocorticoids do not prevent asthma exacerbations in children: The STICS trial

In children aged 5 to 11 years with mild to moderate persistent asthma who were treated with daily inhaled glucocorticoids, quintupling the dose during the initial signs of worsening asthma control did not reduce the rate of severe exacerbations.

A 32-Year-Old Pregnant Woman Presents With Worsening Dyspnea

A 32-Year-Old Pregnant Woman Presents With Worsening Dyspnea

Several months after being diagnosed with pulmonary arterial hypertension, a 32-year-old pregnant woman presents with worsening dyspnea.

Immunotherapy With Grass Allergen Peptides Reduced Seasonal Allergy Symptoms

Immunotherapy With Grass Allergen Peptides Reduced Seasonal Allergy Symptoms

Adults with grass pollen rhinoconjunctivitis benefited from immunotherapy with peptide hydrolysates from Lolium perenne.

PDE-5 Inhibitor Prescribing Trends in US Veterans With Pulmonary Hypertension

PDE-5 Inhibitor Prescribing Trends in US Veterans With Pulmonary Hypertension

Nearly two-thirds of phosphodiesterase-5 inhibitor prescriptions for US veterans are inconsistent with pulmonary hypertension guidelines.

Ventilator-Free Days in ICU With On-Demand vs Routine Nebulization

Ventilator-Free Days in ICU With On-Demand vs Routine Nebulization

On-demand nebulization of acetylcysteine with salbutamol did not result in an inferior number of ventilator-free days compared with routine nebulization.

Severe Asthmatic Cough May Be Improved With Bronchial Thermoplasty

Severe Asthmatic Cough May Be Improved With Bronchial Thermoplasty

Bronchial thermoplasty can treat severe asthmatic cough that is unresponsive to conventional therapies.

Cystic Fibrosis-Related Pathogen Risk With Chronic Azithromycin Use

Cystic Fibrosis-Related Pathogen Risk With Chronic Azithromycin Use

Patients with cystic fibrosis who took azithromycin had a significantly lower risk for detection of new nontuberculous mycobacteria, methicillin-resistant Staphylococcus aureus, and Burkholderia cepacia complex.

COPD Combination Therapy May Improve Lung Hyperinflation

COPD Combination Therapy May Improve Lung Hyperinflation

Combination treatment with indacaterol-glycopyrronium may improve cardiac function in patients with chronic obstructive pulmonary disease.

Glucocorticoids Do Not Increase Fracture Risk in COPD

Glucocorticoids Do Not Increase Fracture Risk in COPD

Intermittent use of high-dose glucocorticoids did not increase the risk for fracture in patients with COPD.

Revisit to ED May Indicate Poor Outcomes in Elderly Patients

Revisit to ED May Indicate Poor Outcomes in Elderly Patients

A revisit to the emergency department within 30 days of a previous visit predicted poor outcomes in elderly adults.

Severe COPD Exacerbations, Hospitalizations Reduced With Azithromycin

Severe COPD Exacerbations, Hospitalizations Reduced With Azithromycin

Long-term continuous cyclic azithromycin therapy for severe chronic obstructive pulmonary disease was associated with reductions in exacerbations and hospitalizations.

Asthma Medications May Negatively Affect Fertility in Women

Asthma Medications May Negatively Affect Fertility in Women

Short-acting beta-agonists for asthma management may reduce fertility rates in women with asthma.

Airway Management Methods During ACLS: Jury Still Out

Airway Management Methods During ACLS: Jury Still Out

A study sought to determine whether bag-mask ventilation was noninferior to endotracheal intubation as initial airway management during advanced cardiac life support during out-of-hospital cardiac arrest.

Biomarkers May Identify Patients at Increased Risk for Severe Asthma Exacerbations

Biomarkers May Identify Patients at Increased Risk for Severe Asthma Exacerbations

Fractional exhaled nitric oxide, periostin, and eosinophils may help identify patients at increased risk for severe asthma exacerbations, according to a post hoc analysis of a phase 2b trial on dupilumab.

Chronic Oral Glucocorticoid Use in Pediatric Asthma May Increase Morbidities

Chronic Oral Glucocorticoid Use in Pediatric Asthma May Increase Morbidities

Children with asthma who experience chronic oral glucocorticoid exposure may have significant morbidities, including adrenal suppression, recurrent pneumonia, and behavioral problems.

Mepolizumab Effective in Asthma After Failed Response to Omalizumab

Mepolizumab Effective in Asthma After Failed Response to Omalizumab

Mepolizumab may be effective in patients with asthma that does not respond to omalizumab.

Safety, Efficacy of Quintupled Inhaled Glucocorticoid Dose for Asthma Exacerbation Management

Safety, Efficacy of Quintupled Inhaled Glucocorticoid Dose for Asthma Exacerbation Management

Children with mild to moderate persistent asthma were not more effectively treated with a quintupled dose of inhaled glucocorticoids.

Uncontrolled Asthma Improved With Tezepelumab

Uncontrolled Asthma Improved With Tezepelumab

Tezepelumab improved asthma control in patients with severe or uncontrolled asthma.

Benralizumab Effective for Uncontrolled Eosinophilic Asthma and Nasal Polyps

Benralizumab Effective for Uncontrolled Eosinophilic Asthma and Nasal Polyps

A post-hoc pooled analysis of phase 3 SIROCCO and CALIMA trials demonstrated benralizumab to be effective in the treatment of individuals with severe, uncontrolled eosinophilic asthma and nasal polyps.

Safety and Adverse Events Associated With Inhaled Corticosteroids for Asthma

Safety and Adverse Events Associated With Inhaled Corticosteroids for Asthma

Researchers performed a literature review and summarized the evidence regarding adverse events associated with the use of inhaled corticosteroids in individuals with asthma.

Drainage Duration, Length of Hospital Stay With Different Pneumothorax Treatments

Drainage Duration, Length of Hospital Stay With Different Pneumothorax Treatments

Treatment with a small pigtail catheter may shorten the drainage duration and length of hospital stay in patients with spontaneous pneumothorax.

Concomitant Use of Beta-Blockers, Beta-Agonists in COPD With CV Risk

Concomitant Use of Beta-Blockers, Beta-Agonists in COPD With CV Risk

Patients with COPD and heightened cardiovascular risk received respiratory benefits from long-acting beta-agonist therapy without increasing their cardiovascular risk, regardless of beta-blocker therapy.

Effect of Haloperidol in Critically Ill Patients at Risk for Delirium

Effect of Haloperidol in Critically Ill Patients at Risk for Delirium

Prophylactic haloperidol does not improve survival at 28 days compared with placebo in critically ill adults

Pulmonary Embolism With Low Mortality Risk May Be Managed in Outpatient Setting

Pulmonary Embolism With Low Mortality Risk May Be Managed in Outpatient Setting

Observation in the emergency department followed by outpatient management with anticoagulation may be appropriate treatment for some patients with low-risk pulmonary embolism.

Long-Term Inhaled Corticosteroid Use in COPD May Increase Fracture Risk

Long-Term Inhaled Corticosteroid Use in COPD May Increase Fracture Risk

Patients with chronic obstructive pulmonary disease had a modest increased risk for hip and upper extremity fractures when taking long-term, high-dose inhaled corticosteroids.

Influenza Can Be Inactivated Using Far-Ultraviolet C Light

Influenza Can Be Inactivated Using Far-Ultraviolet C Light

Airborne influenza viruses may be safely and effectively eradicated with continuous low doses of far ultraviolet C light.

COPD-Related Lung Transplantation: How Can We Improve Survival Rates?

COPD-Related Lung Transplantation: How Can We Improve Survival Rates?

Lung transplantation can improve survival in patients with chronic obstructive pulmonary disease, but several variables can affect the surgery's success.

Shorter pediatric tuberculosis treatment linked to higher completion rates

Children with tuberculosis who received 3 months of directly observed preventive therapy were 25 times more likely to complete their treatment regimen than those who received 9 months of self-administered therapy.

A 56-Year-Old Woman Presents With Upper Respiratory Infection With Mild Fever

A 56-Year-Old Woman Presents With Upper Respiratory Infection With Mild Fever

A 56-year-old woman who received a heart transplant 1 year ago because of dilated cardiomyopathy now presents with mild fever and generalized weakness.

FDA Approves New CFTR Modulator Therapy for Cystic Fibrosis

FDA Approves New CFTR Modulator Therapy for Cystic Fibrosis

A new cystic fibrosis transmembrane conductance regulator modulator treatment has been approved by the FDA for use in patients aged 12 years and older.

Neonates With Respiratory Distress Syndrome: Does Inhaled Nitric Oxide Reduce Mortality?

Neonates With Respiratory Distress Syndrome: Does Inhaled Nitric Oxide Reduce Mortality?

Off-label use of inhaled nitric oxide is not associated with reduced mortality in neonates born at 22 to 29 weeks'gestation with RDS.

Obstructive Sleep Apnea: Effectiveness of Oronasal vs Nasal CPAP

Obstructive Sleep Apnea: Effectiveness of Oronasal vs Nasal CPAP

Oronasal masks may not be as effective as nasal masks for the treatment of obstructive sleep apnea.

Cystic Fibrosis Foundation Recommends CFTR Modulator Therapy in Select Patients

Cystic Fibrosis Foundation Recommends CFTR Modulator Therapy in Select Patients

CFTR modulator therapy recommended in certain patients with cystic fibrosis.

Antibiotics for Acute Exacerbations in COPD: Comparison of Effectiveness and Tolerability

Antibiotics for Acute Exacerbations in COPD: Comparison of Effectiveness and Tolerability

Researchers compared the clinical cure and adverse effect rates of multiple antibiotics in the treatment of acute exacerbations in chronic obstructive pulmonary disease.

Invasive Mechanical Ventilation in Severe CAP Increased Mortality Risk

Invasive Mechanical Ventilation in Severe CAP Increased Mortality Risk

Invasive mechanical ventilation in patients with severe community-acquired pneumonia appeared to increase their mortality risk.

Surgical Monitoring in Chronic Lung Disease Using Biodegradable Sensors

Surgical Monitoring in Chronic Lung Disease Using Biodegradable Sensors

A new biodegradable pressure sensor device may make monitoring patients with chronic lung disease easier during surgery.

Guiding COPD Management Using Airway Branch Variation

Guiding COPD Management Using Airway Branch Variation

Researchers examined variation in airway branches to determine whether they have an effect on the course of chronic obstructive pulmonary disease.

COPD Exercise Capacity With Long-Acting Bronchodilators

COPD Exercise Capacity With Long-Acting Bronchodilators

Patients with COPD experienced a weighted mean increase in exercise endurance time following treatment with long-acting bronchodilators.

FDA Approves Avycaz Supplemental NDA for Pneumonia

FDA Approves Avycaz Supplemental NDA for Pneumonia

The FDA approved the supplemental New Drug Application for Avycaz to treat adults with hospital-acquired or ventilator-associated bacterial pneumonia.

Oral Prednisolone for the Management of Pediatric Wheezing

Oral Prednisolone for the Management of Pediatric Wheezing

Children who received oral prednisolone vs placebo for virus-associated wheeze had a shorter length of hospital stay.

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