Combination therapy with LABA and LAMA yielded a lower annualized rate of COPD exacerbations compared with triple therapy.
While macrolides had no direct effect on lung function, their use significantly improved asthma control and quality of life in patients with asthma.
Fixed continuous positive airway pressure for the treatment of obstructive sleep apnea was associated with preventing a time-dependent decline in estimated glomerular filtration rate.
Nasal beclomethasone dipropionate was more effective in improving nasal patency and cytology as well as quality of life compared with cetirizine in children with perennial allergic rhinitis.
The initiative helped reduce the ordering of chest radiographs, respiratory viral testing, and bronchodilators.
The study authors reported, "The most commonly reported problems by youth were: (a) hard to remember when to take the asthma medication (54%) and (b) hard to use asthma medication at school (34%)."
At the end of 6 months, the rate of VTE recurrence was 4% among rivaroxaban patients vs 11% in the dalteparin arm (hazard ratio [HR] 0.43, 95% CI: 0.19 to 0.99).
Of the total 573 APFS dispensed, 1 malfunctioned and 1 was considered nonfunctional because it was not returned. The study authors also reported that patient-use error only led to 2 unsuccessful at-home administrations.
The study aimed to determine the association between ICS therapy adherence and the occurrence of asthma exacerbations in patients with high blood eosinophil levels.
Copeptin may be useful for identifying normotensive patients with pulmonary embolism who have a higher risk for an adverse outcome.
PHQ-9 and PHQ-2 show factorial validity, invariance, and reliability for measuring depression in patients with chronic obstructive pulmonary disease.
In patients with pulmonary arterial hypertension who were treated with a parenteral prostanoid, survival was linked with the number of guideline-recommended lower-risk and higher-risk criteria attained.
Emerging guidelines for diagnosing and treating asthma COPD overlap syndrome will help clinicians better manage patients and prevent serious adverse effects.
The sNDA is accompanied by results from the MERIT-1 trial, a Phase 2 randomized, placebo-controlled, double-blind study which assessed the efficacy, safety and tolerability of macitentan 10mg in 80 patients with inoperable CTEPH.
Children with status asthmaticus who received magnesium sulfate therapy were on continuous albuterol for a longer duration.
Stem cell therapy targeting right ventricular failure may help improve pulmonary circulation in pulmonary arterial hypertension.
Adding olodaterol to tiotropium did not significantly reduce exacerbations in patients with chronic obstructive pulmonary disease as much as researchers had anticipated.
The drug consists of fluticasone furoate, an inhaled corticosteroid (ICS), umeclidinium, a long-acting muscarinic antagonist, and vilanterol, a long-acting beta2-adrenergic agonist (LABA), delivered via an Ellipta dry powder inhaler.
This updated Committee Opinion includes more recent data on the safety and efficacy of influenza vaccination during pregnancy, as well as recommendations for treatment and postexposure chemoprophylaxis.
In patients with COPD, transcatheter aortic valve replacement was associated with fewer respiratory-related complications than surgical aortic valve replacement.
Statins have anti-inflammatory and anti-oxidative effects, which could reduce exacerbations of both asthma and chronic obstructive pulmonary disease.
Adult caretaker influenza vaccination cocooning programs can prove beneficial and financially successful in private practice models where external funding is limited or not available.
Triple therapy with fluticasone furoate, umeclidinium, and vilanterol was associated with a lower rate of exacerbations in chronic obstructive pulmonary disease.
During the cold and flu season, the use and over-dosing of paracetamol is common, and may partially be driven by higher use of over-the-counter combination medications for the treatment of upper respiratory cold/flu symptoms.
Both chest tube placement and needle aspiration were considered acceptable treatments for primary spontaneous pneumothorax.
Nivolumab plus ipilimumab linked to better survival in NSCLC with high tumor mutational burden.
No significant benefit of long-acting muscarinic antagonists over long-acting beta-agonists in reducing exacerbation risk in uncontrolled, persistent asthma
Adjunct long-acting muscarinic antagonist (LAMA) use with corticosteroids was associated with reduced exacerbation risk compared with placebo in patients with uncontrolled, persistent asthma. However, LAMA, long-acting beta-agonist (LABA), and inhaled corticosteroids (triple therapy) were not associated with lower risk for exacerbations compared with LABA and inhaled corticosteroids alone.
Balanced crystalloids decreases adverse kidney events compared to saline among critically ill patients: The SMART trial
Use of balanced crystalloids (lactated Ringers or Plasma-Lyte A) was associated with a significant reduction in acute kidney injury events compared with normal saline among intensive care unit (ICU) patients. Use of balanced crystalloids was also associated with lower though nonsignificant in-hospital mortality at 30-days after admission.
Continuous positive airway pressure (CPAP) remains the mainstay of medical treatment for OSA.
Treating chronic obstructive pulmonary disease remains challenging, particularly in terms of choosing the appropriate fixed-dose combination bronchodilator.
Bedaquiline and delamanid were effective and well tolerated in patients with multidrug-resistant tuberculosis.
Prescribers tend to favor a frequency of 3 times per day for oral treprostinil dosing in patients with pulmonary arterial hypertension.
RP5063 is a new chemical entity with a novel mechanism of multimodal modulation of serotonin and dopamine signaling pathways.
Early intervention in the case of respiratory compromise in patients with multiple sclerosis has the potential to prevent infection and maintain pulmonary function.
In patients with persistent asthma, single maintenance and reliever therapy was associated with a lower risk for exacerbations compared with inhaled corticosteroids as controller therapy and short-acting beta-agonists as relief therapy.
The risk for death in patients with community-acquired pneumonia who were given mechanical ventilation does not seem to be affected by the presence of acute respiratory distress syndrome.
Tai chi found to be as effective as pulmonary rehabilitation for patients with chronic obstructive pulmonary disease.
Researchers found stronger negative associations for participants with polypharmacy between the ages of 60 and 64 years and at 69 years.
It is still not known whether differences in mortality rates between patients who receive noninvasive vs invasive ventilation for acute exacerbations of COPD can be attributed to less severe disease or other factors.
Regardless of blood eosinophil count, omalizumab was an effective treatment in adult and pediatric patients with severe allergic asthma.
Dacomitinib is a pan-human epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor.
Proteostasis Therapeutics is developing the combination treatment which includes a novel transmembrane conductance regulator (CFTR) amplifier (PTI-428), a third generation corrector (PTI-801) and a potentiator (PTI-808).
Only 16.5% of pharmacy customers with hay fever select optimal medications.
Lonhala Magnair is available as a 25mcg strength inhalation solution per 1mL vial.
Sinuva can be implanted during a routine physician visit under local or topical anesthesia.
More than 90% of non-azithromycin antibiotic courses were 10 days or longer for acute sinusitis.
Study authors concluded, "Combining tiotropium and olodaterol did not reduce exacerbation rate as much as expected compared with tiotropium alone."
ALIS has previously been designated orphan drug status, breakthrough therapy status and a Qualified Infectious Disease Product.
Disease management added to recommended care in chronic obstructive pulmonary disease was not superior to recommended care alone.
Four different doses of glycopyrronium delivered via metered dose inhaler were compared for safety and efficacy in the treatment of chronic obstructive pulmonary disease.
Patients with asthma or chronic obstructive pulmonary disease have especially high rates of nonadherence, even in comparison with other chronic diseases.
The Smartinhaler sensor is a device installed onto a patient's inhaler to monitor and promote asthma and COPD medication adherence.
A higher percentage of critically ill patients in the intensive care unit who were given nocturnal dexmedetomidine remained delirium free compared with placebo.
Use of prophylactic antimicrobial therapy was not associated with a reduction in mortality or transfer to critical care compared with patients managed with supportive care only.
HIV-positive patients with pulmonary tuberculosis benefited from daily antituberculosis therapy in terms of effectiveness and rifampicin resistance.
Long-acting muscarinic antagonists or long-acting β-agonists plus inhaled corticosteroids lowered the risk for asthma exacerbations vs adjuvant placebo.
Shorter treatment regimens for tuberculosis were associated with increased completion rates and fewer adverse events compared with traditional regimens.
There was no significant correlation with suicide for oseltamavir exposure or for influenza diagnosis alone.
Prophylactic haloperidol did not reduce delirium incidence, delirium-free days, duration of mechanical ventilation, or hospital length of stay in patients in the intensive care unit.
Patients with septic shock in the intensive care unit undergoing mechanical ventilation and managed with adjunctive continuous hydrocortisone infusion did not have a lower 90-day mortality compared with placebo.
In children aged 5 to 11 years with mild to moderate persistent asthma who were treated with daily inhaled glucocorticoids, quintupling the dose during the initial signs of worsening asthma control did not reduce the rate of severe exacerbations.
Several months after being diagnosed with pulmonary arterial hypertension, a 32-year-old pregnant woman presents with worsening dyspnea.
Adults with grass pollen rhinoconjunctivitis benefited from immunotherapy with peptide hydrolysates from Lolium perenne.
Nearly two-thirds of phosphodiesterase-5 inhibitor prescriptions for US veterans are inconsistent with pulmonary hypertension guidelines.
On-demand nebulization of acetylcysteine with salbutamol did not result in an inferior number of ventilator-free days compared with routine nebulization.
Bronchial thermoplasty can treat severe asthmatic cough that is unresponsive to conventional therapies.
Patients with cystic fibrosis who took azithromycin had a significantly lower risk for detection of new nontuberculous mycobacteria, methicillin-resistant Staphylococcus aureus, and Burkholderia cepacia complex.
Combination treatment with indacaterol-glycopyrronium may improve cardiac function in patients with chronic obstructive pulmonary disease.
Intermittent use of high-dose glucocorticoids did not increase the risk for fracture in patients with COPD.
A revisit to the emergency department within 30 days of a previous visit predicted poor outcomes in elderly adults.
Long-term continuous cyclic azithromycin therapy for severe chronic obstructive pulmonary disease was associated with reductions in exacerbations and hospitalizations.
Short-acting beta-agonists for asthma management may reduce fertility rates in women with asthma.
A study sought to determine whether bag-mask ventilation was noninferior to endotracheal intubation as initial airway management during advanced cardiac life support during out-of-hospital cardiac arrest.
Fractional exhaled nitric oxide, periostin, and eosinophils may help identify patients at increased risk for severe asthma exacerbations, according to a post hoc analysis of a phase 2b trial on dupilumab.
Children with asthma who experience chronic oral glucocorticoid exposure may have significant morbidities, including adrenal suppression, recurrent pneumonia, and behavioral problems.
Mepolizumab may be effective in patients with asthma that does not respond to omalizumab.
Children with mild to moderate persistent asthma were not more effectively treated with a quintupled dose of inhaled glucocorticoids.
Tezepelumab improved asthma control in patients with severe or uncontrolled asthma.
A post-hoc pooled analysis of phase 3 SIROCCO and CALIMA trials demonstrated benralizumab to be effective in the treatment of individuals with severe, uncontrolled eosinophilic asthma and nasal polyps.
Researchers performed a literature review and summarized the evidence regarding adverse events associated with the use of inhaled corticosteroids in individuals with asthma.
Treatment with a small pigtail catheter may shorten the drainage duration and length of hospital stay in patients with spontaneous pneumothorax.
Patients with COPD and heightened cardiovascular risk received respiratory benefits from long-acting beta-agonist therapy without increasing their cardiovascular risk, regardless of beta-blocker therapy.
Prophylactic haloperidol does not improve survival at 28 days compared with placebo in critically ill adults
Observation in the emergency department followed by outpatient management with anticoagulation may be appropriate treatment for some patients with low-risk pulmonary embolism.
Patients with chronic obstructive pulmonary disease had a modest increased risk for hip and upper extremity fractures when taking long-term, high-dose inhaled corticosteroids.
Airborne influenza viruses may be safely and effectively eradicated with continuous low doses of far ultraviolet C light.
Lung transplantation can improve survival in patients with chronic obstructive pulmonary disease, but several variables can affect the surgery's success.
Children with tuberculosis who received 3 months of directly observed preventive therapy were 25 times more likely to complete their treatment regimen than those who received 9 months of self-administered therapy.
A 56-year-old woman who received a heart transplant 1 year ago because of dilated cardiomyopathy now presents with mild fever and generalized weakness.
A new cystic fibrosis transmembrane conductance regulator modulator treatment has been approved by the FDA for use in patients aged 12 years and older.
Off-label use of inhaled nitric oxide is not associated with reduced mortality in neonates born at 22 to 29 weeks'gestation with RDS.
Oronasal masks may not be as effective as nasal masks for the treatment of obstructive sleep apnea.
CFTR modulator therapy recommended in certain patients with cystic fibrosis.
Researchers compared the clinical cure and adverse effect rates of multiple antibiotics in the treatment of acute exacerbations in chronic obstructive pulmonary disease.
Invasive mechanical ventilation in patients with severe community-acquired pneumonia appeared to increase their mortality risk.
A new biodegradable pressure sensor device may make monitoring patients with chronic lung disease easier during surgery.
Researchers examined variation in airway branches to determine whether they have an effect on the course of chronic obstructive pulmonary disease.
Patients with COPD experienced a weighted mean increase in exercise endurance time following treatment with long-acting bronchodilators.
The FDA approved the supplemental New Drug Application for Avycaz to treat adults with hospital-acquired or ventilator-associated bacterial pneumonia.
Children who received oral prednisolone vs placebo for virus-associated wheeze had a shorter length of hospital stay.