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COPD, Asthma, or Asthma COPD Overlap Syndrome: Diagnostic Challenges

COPD, Asthma, or Asthma COPD Overlap Syndrome: Diagnostic Challenges

Emerging guidelines for diagnosing and treating asthma COPD overlap syndrome will help clinicians better manage patients and prevent serious adverse effects.

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Cannabidiol Gets Orphan Drug Status for Preventing Ischemia-Reperfusion Injury

Cannabidiol Gets Orphan Drug Status for Preventing Ischemia-Reperfusion Injury

The designation was granted to Revive Therapeutics, a company that specializes in cannabis-based pharmaceuticals.

Omalizumab Inhibits Respiratory Reactions During Aspirin Desensitization

Omalizumab Inhibits Respiratory Reactions During Aspirin Desensitization

In patients with aspirin exacerbated respiratory disease, treatment with omalizumab resulted in "clinically silent" aspirin desensitization.

Asthma Exacerbation Risk With As-Needed Budesonide-Formoterol vs Maintenance Budesonide

Asthma Exacerbation Risk With As-Needed Budesonide-Formoterol vs Maintenance Budesonide

Budesonide-formoterol as needed was not inferior compared with budesonide maintenance therapy in terms of severe asthma exacerbation rates, but may be inferior for controlling symptoms.

Effectiveness of Budesonide-Formoterol vs Terbutaline in Asthma Symptom Control

Effectiveness of Budesonide-Formoterol vs Terbutaline in Asthma Symptom Control

There was a 60% lower rate of severe asthma exacerbations in individuals treated with budesonide-formoterol compared with individuals treated with terbutaline as needed.

Early Clinical Response With Omadacycline vs Moxifloxacin in CABP

Early Clinical Response With Omadacycline vs Moxifloxacin in CABP

Early clinical response rates were similar across PORT risk class subgroups in patients with community-acquired bacterial pneumonia when treated with omadacycline or moxifloxacin.

Prevnar 13 Linked to Reduced Risk of CAP Hospitalization in Older Patients

Prevnar 13 Linked to Reduced Risk of CAP Hospitalization in Older Patients

PCV13, marketed as Prevnar 13, was evaluated in a test-negative case-control study in real-world conditions where patients were administered pneumococcal vaccination as advised by their healthcare providers.

Mortality Increased With Liberal Oxygen Therapy in Acutely Ill Patients

Mortality Increased With Liberal Oxygen Therapy in Acutely Ill Patients

Liberal supplemental oxygen therapy in acutely ill patients increased mortality during hospitalization, at 30 days, and at longest follow-up.

Positive Results Announced for Pleuromutilin Antibiotic in CABP

Positive Results Announced for Pleuromutilin Antibiotic in CABP

In the LEAP 2 study (N=738), patients with moderate CABP received either oral lefamulin 600mg every 12 hours for 5 days or oral moxifloxacin 400mg once daily for 7 days.

High-Flow Nasal Cannula vs Conventional Oxygen Therapy for Acute Respiratory Failure

High-Flow Nasal Cannula vs Conventional Oxygen Therapy for Acute Respiratory Failure

In patients with acute respiratory failure, high-flow nasal cannula and conventional oxygen therapy provided similar benefits.

Tiotropium/Olodaterol Combination vs Tiotropium Alone for Severe COPD Exacerbations

Tiotropium/Olodaterol Combination vs Tiotropium Alone for Severe COPD Exacerbations

Tiotropium may be more effective in reducing the rate of moderate and severe chronic obstructive pulmonary disorder exacerbations when used in combination with olodaterol vs tiotropium alone.

Budesonide Improved Epithelial Barrier Function in Asthma

Budesonide Improved Epithelial Barrier Function in Asthma

Researchers evaluated barrier dysfunction by exposing viral models to budesonide, montelukast, formoterol, or a combination.

Inhaled Interferon-Beta 1a Does Not Reduce Severe Asthma Exacerbations

Inhaled Interferon-Beta 1a Does Not Reduce Severe Asthma Exacerbations

Inhaled interferon-beta 1 a did not significantly reduce acute asthma exacerbations during respiratory viral infections.

COPD Frequently Misdiagnosed, Undiagnosed in Individuals With or Without HIV

COPD Frequently Misdiagnosed, Undiagnosed in Individuals With or Without HIV

In this study, researchers examined the appropriateness of diagnosis and treatment of chronic obstructive pulmonary disease in individuals with and without HIV.

Morning vs Evening ICS Dosing in Asthma: Efficacies Compared

Morning vs Evening ICS Dosing in Asthma: Efficacies Compared

Inhaled corticosteroids for asthma dosed once daily in the evening appeared to offer some benefit in trough FEV1 and morning peak expiratory flow.

Steroid Dosing, Glucose Levels Do Not Increase Likelihood of COPD Readmissions

Steroid Dosing, Glucose Levels Do Not Increase Likelihood of COPD Readmissions

Steroid dosing and glucose levels were not associated with an increase in hospital readmissions related to COPD exacerbations.

Mortality Rates in Extrafine ICS-Containing vs ICS-Free Medications in COPD

Mortality Rates in Extrafine ICS-Containing vs ICS-Free Medications in COPD

The pooled safety analysis included data from the TRILOGY, TRINITY, and TRIBUTE studies.

Incident Diuretic Use May Increase Adverse Events in COPD

Incident Diuretic Use May Increase Adverse Events in COPD

Incident diuretic use was associated with increased rates of respiratory-related morbidity and mortality in older adults with chronic obstructive pulmonary disease.

Efficacy, Safety of Dupilumab in Corticosteroid-Dependent Severe Asthma

Efficacy, Safety of Dupilumab in Corticosteroid-Dependent Severe Asthma

Subcutaneous dupilumab significantly reduced the use of oral corticosteroids in patients with corticosteroid-dependent severe asthma.

Lung Function in Severe Asthma Improved With Benralizumab

Lung Function in Severe Asthma Improved With Benralizumab

Peak expiratory flow increases were greater with benralizumab than placebo in patients with severe eosinophilic asthma.

Vitamin D Supplementation Improves Asthma Control

Vitamin D Supplementation Improves Asthma Control

In individuals with asthma and vitamin D deficiency, vitamin D supplementation improved asthma control.

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