Treatments

Incident Diuretic Use May Increase Adverse Events in COPD

Incident Diuretic Use May Increase Adverse Events in COPD

Incident diuretic use was associated with increased rates of respiratory-related morbidity and mortality in older adults with chronic obstructive pulmonary disease.

Mortality Rates in Extrafine ICS-Containing vs ICS-Free Medications in COPD

Mortality Rates in Extrafine ICS-Containing vs ICS-Free Medications in COPD

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The pooled safety analysis included data from the TRILOGY, TRINITY, and TRIBUTE studies.

Efficacy, Safety of Dupilumab in Corticosteroid-Dependent Severe Asthma

Efficacy, Safety of Dupilumab in Corticosteroid-Dependent Severe Asthma

Subcutaneous dupilumab significantly reduced the use of oral corticosteroids in patients with corticosteroid-dependent severe asthma.

Lung Function in Severe Asthma Improved With Benralizumab

Lung Function in Severe Asthma Improved With Benralizumab

Peak expiratory flow increases were greater with benralizumab than placebo in patients with severe eosinophilic asthma.

Vitamin D Supplementation Improves Asthma Control

Vitamin D Supplementation Improves Asthma Control

In individuals with asthma and vitamin D deficiency, vitamin D supplementation improved asthma control.

Effect of Combination vs Triple Therapy on COPD Exacerbations

Effect of Combination vs Triple Therapy on COPD Exacerbations

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Combination therapy with LABA and LAMA yielded a lower annualized rate of COPD exacerbations compared with triple therapy.

Macrolides for Asthma Management: An Updated Review

Macrolides for Asthma Management: An Updated Review

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While macrolides had no direct effect on lung function, their use significantly improved asthma control and quality of life in patients with asthma.

Fixed vs Auto-Adjusting CPAP for Prevention of eGFR Decline in OSA

Fixed vs Auto-Adjusting CPAP for Prevention of eGFR Decline in OSA

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Fixed continuous positive airway pressure for the treatment of obstructive sleep apnea was associated with preventing a time-dependent decline in estimated glomerular filtration rate.

Beclomethasone Dipropionate vs Cetirizine in Children With Perennial Allergic Rhinitis

Beclomethasone Dipropionate vs Cetirizine in Children With Perennial Allergic Rhinitis

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Nasal beclomethasone dipropionate was more effective in improving nasal patency and cytology as well as quality of life compared with cetirizine in children with perennial allergic rhinitis.

Initiative Cuts Overuse of Tests, Treatments for Bronchiolitis

Initiative Cuts Overuse of Tests, Treatments for Bronchiolitis

The initiative helped reduce the ordering of chest radiographs, respiratory viral testing, and bronchodilators.

Most Concerning Med Issues Explored Among Youth With Asthma

Most Concerning Med Issues Explored Among Youth With Asthma

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The study authors reported, "The most commonly reported problems by youth were: (a) hard to remember when to take the asthma medication (54%) and (b) hard to use asthma medication at school (34%)."

Oral Anticoagulant Effective in Recurrent VTE Prevention in Cancer Patients

Oral Anticoagulant Effective in Recurrent VTE Prevention in Cancer Patients

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At the end of 6 months, the rate of VTE recurrence was 4% among rivaroxaban patients vs 11% in the dalteparin arm (hazard ratio [HR] 0.43, 95% CI: 0.19 to 0.99).

ICS Therapy May Not Be Enough for Asthma Patients With Elevated Eosinophils

ICS Therapy May Not Be Enough for Asthma Patients With Elevated Eosinophils

The study aimed to determine the association between ICS therapy adherence and the occurrence of asthma exacerbations in patients with high blood eosinophil levels.

Feasibility of At-Home Use Injectable Tx for Severe Asthma Assessed

Feasibility of At-Home Use Injectable Tx for Severe Asthma Assessed

Of the total 573 APFS dispensed, 1 malfunctioned and 1 was considered nonfunctional because it was not returned. The study authors also reported that patient-use error only led to 2 unsuccessful at-home administrations.

Copeptin May Serve as Prognostic Biomarker for Pulmonary Embolism

Copeptin May Serve as Prognostic Biomarker for Pulmonary Embolism

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Copeptin may be useful for identifying normotensive patients with pulmonary embolism who have a higher risk for an adverse outcome.

Assessing Depression Following Inpatient COPD Rehabilitation

Assessing Depression Following Inpatient COPD Rehabilitation

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PHQ-9 and PHQ-2 show factorial validity, invariance, and reliability for measuring depression in patients with chronic obstructive pulmonary disease.

Survival Rates With Parenteral Prostanoids in Pulmonary Arterial Hypertension

Survival Rates With Parenteral Prostanoids in Pulmonary Arterial Hypertension

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In patients with pulmonary arterial hypertension who were treated with a parenteral prostanoid, survival was linked with the number of guideline-recommended lower-risk and higher-risk criteria attained.

COPD, Asthma, or Asthma COPD Overlap Syndrome: Diagnostic Challenges

COPD, Asthma, or Asthma COPD Overlap Syndrome: Diagnostic Challenges

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Emerging guidelines for diagnosing and treating asthma COPD overlap syndrome will help clinicians better manage patients and prevent serious adverse effects.

Opsumit sNDA Submitted for Chronic Thromboembolic Pulmonary Hypertension

Opsumit sNDA Submitted for Chronic Thromboembolic Pulmonary Hypertension

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The sNDA is accompanied by results from the MERIT-1 trial, a Phase 2 randomized, placebo-controlled, double-blind study which assessed the efficacy, safety and tolerability of macitentan 10mg in 80 patients with inoperable CTEPH.

Children With Status Asthmaticus Do Not Benefit From Magnesium Sulfate

Children With Status Asthmaticus Do Not Benefit From Magnesium Sulfate

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Children with status asthmaticus who received magnesium sulfate therapy were on continuous albuterol for a longer duration.

Stem Cell Therapy for RV Failure in PAH: Overview and Clinician Interview

Stem Cell Therapy for RV Failure in PAH: Overview and Clinician Interview

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Stem cell therapy targeting right ventricular failure may help improve pulmonary circulation in pulmonary arterial hypertension.

Addition of Olodaterol to Tiotropium Does Not Significantly Reduce COPD Exacerbations

Addition of Olodaterol to Tiotropium Does Not Significantly Reduce COPD Exacerbations

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Adding olodaterol to tiotropium did not significantly reduce exacerbations in patients with chronic obstructive pulmonary disease as much as researchers had anticipated.

Trelegy Ellipta Gains Expanded COPD Indication, Loses Boxed Warning

Trelegy Ellipta Gains Expanded COPD Indication, Loses Boxed Warning

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The drug consists of fluticasone furoate, an inhaled corticosteroid (ICS), umeclidinium, a long-acting muscarinic antagonist, and vilanterol, a long-acting beta2-adrenergic agonist (LABA), delivered via an Ellipta dry powder inhaler.

ACOG: Updated Recommendations for Influenza Vaccination During Pregnancy

ACOG: Updated Recommendations for Influenza Vaccination During Pregnancy

This updated Committee Opinion includes more recent data on the safety and efficacy of influenza vaccination during pregnancy, as well as recommendations for treatment and postexposure chemoprophylaxis.

Transcatheter vs Surgical Aortic Valve Replacement in COPD

Transcatheter vs Surgical Aortic Valve Replacement in COPD

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In patients with COPD, transcatheter aortic valve replacement was associated with fewer respiratory-related complications than surgical aortic valve replacement.

Breathing New Life Into COPD and Asthma Therapy With Statins

Breathing New Life Into COPD and Asthma Therapy With Statins

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Statins have anti-inflammatory and anti-oxidative effects, which could reduce exacerbations of both asthma and chronic obstructive pulmonary disease.

Adult Caregivers Likely to Receive Influenza Vaccination From Pediatric Clinics

Adult Caregivers Likely to Receive Influenza Vaccination From Pediatric Clinics

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Adult caretaker influenza vaccination cocooning programs can prove beneficial and financially successful in private practice models where external funding is limited or not available.

Triple Therapy Tied to Reduced Rate of COPD Exacerbations

Triple Therapy Tied to Reduced Rate of COPD Exacerbations

Triple therapy with fluticasone furoate, umeclidinium, and vilanterol was associated with a lower rate of exacerbations in chronic obstructive pulmonary disease.

Paracetamol Overuse During Cold and Flu Season

Paracetamol Overuse During Cold and Flu Season

During the cold and flu season, the use and over-dosing of paracetamol is common, and may partially be driven by higher use of over-the-counter combination medications for the treatment of upper respiratory cold/flu symptoms.

Chest Tube Placement vs Needle Aspiration for Spontaneous Pneumothorax

Chest Tube Placement vs Needle Aspiration for Spontaneous Pneumothorax

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Both chest tube placement and needle aspiration were considered acceptable treatments for primary spontaneous pneumothorax.

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