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Could a New Universal Tuberculosis Regimen Help End the TB Pandemic?

Could a New Universal Tuberculosis Regimen Help End the TB Pandemic?

The Lancet Respiratory Medicine staged a debate between proponents and opponents of pan-TB regimens to tackle the current suboptimal worldwide management of TB resistance.

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Amikacin Liposome Inhalation Plus Antibiotics Effective in MAC Lung Disease

Amikacin Liposome Inhalation Plus Antibiotics Effective in MAC Lung Disease

Within 6 months, 23% of patients with Mycobacterium avium complex lung disease who had received add-on amikacin liposome inhalation suspension had a culture conversion.

Tuberculosis Assessment More Efficient With Sputum Molecular Testing

Tuberculosis Assessment More Efficient With Sputum Molecular Testing

In patients with possible tuberculosis, sputum molecular testing may facilitate a more accurate and efficient assessment of disease.

Tuberculosis Relapse May Be Predicted by Isoniazid, Rifampin MICs

Tuberculosis Relapse May Be Predicted by Isoniazid, Rifampin MICs

Higher MIC in pretreatment M. tuberculosis isolates linked to relapse risk.

Rifampin Similar to Isoniazid for Preventing Active Tuberculosis

Rifampin Similar to Isoniazid for Preventing Active Tuberculosis

Rifampin had a significantly higher rate of treatment completion and fewer drug-related adverse events.

Higher Rifampin Dose Effective and Safe in Tuberculosis

Higher Rifampin Dose Effective and Safe in Tuberculosis

Both 15 mg and 20 mg rifampin doses showed a rapid decline in bacteria in patients with tuberculosis.

CDC: Updated Recommendations for Latent TB Infection Treatment

CDC: Updated Recommendations for Latent TB Infection Treatment

In 2017, a Work Group was assembled to conduct a systematic review of 3HP regimen studies published between January 2006 to June 2017, specifically looking at outcomes in children, individuals with HIV/AIDS, and those who self-administered treatment.

Could a New Universal Tuberculosis Regimen Help End the TB Pandemic?

Could a New Universal Tuberculosis Regimen Help End the TB Pandemic?

The Lancet Respiratory Medicine staged a debate between proponents and opponents of pan-TB regimens to tackle the current suboptimal worldwide management of TB resistance.

CDC: Declining Incidence of TB in the United States Remains Inadequate for Elimination

CDC: Declining Incidence of TB in the United States Remains Inadequate for Elimination

Control of active tuberculosis (TB) and a major effort to decrease latent TB infection are both necessary to reduce morbidity and achieve TB elimination in the United States.

A Potential Algorithm for Diagnosing Cavitary Lung Diseases

A Potential Algorithm for Diagnosing Cavitary Lung Diseases

Researchers developed an algorithmic approach to diagnosing lung cavitary diseases.

Bedaquiline and Delamanid Effective in Multidrug-Resistant Tuberculosis

Bedaquiline and Delamanid Effective in Multidrug-Resistant Tuberculosis

Bedaquiline and delamanid were effective and well tolerated in patients with multidrug-resistant tuberculosis.

Cavity Volume and Proximity to Airway May Affect Tuberculosis Treatment

Cavity Volume and Proximity to Airway May Affect Tuberculosis Treatment

Large cavitary lung disease may increase cough frequency that lasts for a longer duration in individuals with tuberculosis.

Effectiveness of Daily vs Thrice-Weekly Tuberculosis Regimens in HIV Patients

Effectiveness of Daily vs Thrice-Weekly Tuberculosis Regimens in HIV Patients

HIV-positive patients with pulmonary tuberculosis benefited from daily antituberculosis therapy in terms of effectiveness and rifampicin resistance.

Shorter Tuberculosis Treatment Regimens Linked to Better Completion Rates

Shorter Tuberculosis Treatment Regimens Linked to Better Completion Rates

Shorter treatment regimens for tuberculosis were associated with increased completion rates and fewer adverse events compared with traditional regimens.

Shorter pediatric tuberculosis treatment linked to higher completion rates

Children with tuberculosis who received 3 months of directly observed preventive therapy were 25 times more likely to complete their treatment regimen than those who received 9 months of self-administered therapy.

Tuberculosis Risk in Type 2 Diabetes Medications

Tuberculosis Risk in Type 2 Diabetes Medications

Patients with type 2 diabetes treated with sulfonylureas had a higher risk of contracting tuberculosis compared with metformin.

Tuberculosis Screening: Updated Recommendations from CHEST

Tuberculosis Screening: Updated Recommendations from CHEST

New recommendations suggest that high risk tuberculosis patients with cough should be screened for pulmonary tuberculosis.

Latent Tuberculosis Testing and Treatment Recommendations

Latent Tuberculosis Testing and Treatment Recommendations

Recommendations for testing and treating latent TB infection have been discussed by a representative from the California Department of Public Health.

Treatment Completion for Latent Tuberculosis

Treatment Completion for Latent Tuberculosis

Self-administered TB therapy should be considered when directly observed therapy is not feasible.

Negative TB Test, Malnutrition, Age Linked to In-Hospital Mortality

Negative TB Test, Malnutrition, Age Linked to In-Hospital Mortality

The relationship between negative tuberculin skin test and in-hospital mortality has not been previously studied.

Time to Sputum Culture Conversion in Isoniazid-Resistant Tuberculosis

Time to Sputum Culture Conversion in Isoniazid-Resistant Tuberculosis

Time to sputum culture conversation was not statistically significant between isoniazid-resistant tuberculosis and isoniazid-suspectible tuberculosis.

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